Results 71 to 80 of about 13,203,537 (398)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Study on the influence of forced ventilation on the maximum fire temperature in roadway heading
Scientific ReportsThis study investigates the maximum temperature in tunnel fires under forced ventilation conditions by constructing a 1:10 scale experimental model and using numerical simulations. A dimensionless derivation of the maximum temperature is provided for the
Bolun Li +8 more
doaj +1 more source
Energy Exploration & Exploitation, 2022 It is significant to predict the gas emission in the mine gob accurately for gas drainage to prevent accidents and ensure safe production. The change of atmospheric pressure makes the gas emission in the mine gob presents a “breathing phenomenon”, which ...
Bing Wu +3 more
doaj +1 more source
Finding Causal Paths between Safety Management System Factors and Accident Precursors
Journal of Management in Engineering, 2020 Understanding the causal relationships between safety management system (SMS) factors and accident precursors helps construction organizations identify which factors require improvement upo...
Estacio Pereira +3 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Dynamic Mechanical Properties of Sandstone Weaken Under Multiple Impacts Based on SHPB Experiments
GeofluidsDue to multiple dynamic disturbances caused by mining activities, the internal fractures in the surrounding rock of the roadway continue to expand, resulting in the continuous weakening of the mechanical properties of the sandstone.
He Yongliang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
IMPLEMENTASI SISTEM MANAJEMEN KESELAMATAN DAN KESEHATAN KERJA (SMK3) DENGAN STANDAR OHSAS 18001 DI PT BINA GUNA KIMIA (AN FMC JOINT VENTURE COMPANY) UNGARAN [PDF]
, 2006 OHSAS 18001 merupakan standar internasional SMK3 yang dipublikasikan oleh BSI bekerjasama dengan lembaga sertifikasi internasional lainnya pada tahun 1999.
YULIANTI, INDAH
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source