Results 71 to 80 of about 12,768,530 (407)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Study on the influence of forced ventilation on the maximum fire temperature in roadway heading

Scientific Reports
This study investigates the maximum temperature in tunnel fires under forced ventilation conditions by constructing a 1:10 scale experimental model and using numerical simulations. A dimensionless derivation of the maximum temperature is provided for the
Bolun Li, Yucheng Li, Yinghao Sun, Wei Zhang, Junqiao Li, Zhitao Zhang, Yunan Cui, Jinyang Dong, Hongwei Liu   +8 more
doaj   +1 more source

Research on multi-parameter inversion of the phenomenon of gob breathing induced by atmospheric pressure fluctuation

Energy Exploration & Exploitation, 2022
It is significant to predict the gas emission in the mine gob accurately for gas drainage to prevent accidents and ensure safe production. The change of atmospheric pressure makes the gas emission in the mine gob presents a “breathing phenomenon”, which ...
Bing Wu, Binbin He, Chenguang Zhao, Baiwei Lei   +3 more
doaj   +1 more source

ANALYSIS, MANAGEMENT AND TRADE-OFF WITH RISKS OF TECHNICAL FACILITIES [PDF]

, 2020
Submitted work “Analysis, management and trade-off with risk of technical facilities“ deals with the all type of risks associated with the technical facilities, particularly with the complex ones, with aim to ensure their safety. It demonstrates the ways
Procházka J., Procházková D.
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Evolution law of overlying rock fracture field in goaf mining with double-roof-cutting retaining roadway

Scientific Reports
This study comprehensively combines physical analog modeling, numerical simulation, on-site monitoring, and other methods to explore the overburden rock fissure development characteristics under double-roof-cutting (DRC) with retained roadway conditions.
Xiaobo Lv, Shengyong Hu, Jun Nian, Chunsheng Deng, Bo Zhao, Cheng He, Yansheng Wang, Xitu Zhang, Wei Zhang   +8 more
doaj   +1 more source

Research on the Dust Diffusion and Pollution Behaviour of Dynamic Tunneling in Header Excavators Based on Dynamic Mesh Technology and Field Measurement

Energies, 2022
In order to accurately characterize and evaluate dust particle diffusion in the dynamic tunneling process of a boring machine, this study considers the 31,116 main transport chute heaving face of the Lijiahao coal mine as a case study.
Xi Chen, Hao Zhang, Shaocheng Ge, Cunbao Deng, Chaonan Fan, Guoliang Ma, Weichao Li   +6 more
doaj   +1 more source

Safety of Aggressive Lipid Management

Journal of the American College of Cardiology, 2007
Data from recent clinical trials of high- versus moderate-dose statin therapy support the recommendation to achieve a low-density lipoprotein (LDL)
Jennifer G. Robinson, Michael H. Davidson   +1 more
openaire   +3 more sources

Penerapan Safety Management System Pada Lembaga Penyelenggara Pelayanan Navigasi Penerbangan Indonesia [PDF]

, 2016
This study aimed to analyze the effect of the implementation of Safety Management System (SMS) and the use of information system on the Flight Safety in the Indonesian Air Navigation Services Organization both partially and simultaneously.
Arofat, O. (Osman), Fiyanzar, A. E. (Adin), Nusraningrum, D. (Dewi)   +2 more
core  

Facing Facts: Facial Injuries from Stand-up Electric Scooters [PDF]

, 2020
Background Stand-up electric scooters (SES) are a popular public transportation method. Numerous safety concerns have arisen since their recent introduction.
Alwani, Mohamedkazim, Bandali, Elhaam, Jones, Alexander J., Lancaster, Benjamin, Sandelski, Morgan, Shipchandler, Taha, Sim, Michael W., Ting, Jonathan   +7 more
core   +1 more source