Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound
FEBS Open Bio, EarlyView.We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda +4 more
wiley +1 more source
Controlled Electromagnetic Field Based Safety System for Handheld Circular Saw. [PDF]
Sensors (Basel), 2022 Teixidó P +5 more
europepmc +1 more source
Notes on Society History: The Origin and Expansion of the System Safety Concept
, 2015 In previous History Notes, I have addressed the genesis of our Society. Here, I will address the development of the system safety concept (SSC). The impetus for this was a request from Charlie Hoes (author of the Journal of System Safety column “TBD”) to
Gordon, Rex
core +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Neurophysiological Assessment of An Innovative Maritime Safety System in Terms of Ship Operators' Mental Workload, Stress, and Attention in the Full Mission Bridge Simulator. [PDF]
Brain Sci, 2023 Ronca V +18 more
europepmc +1 more source
Eliminating or Controlling System Risks via Effective System Safety Requirements and Standards [PDF]
, 2014 When addressing system risks, an overly simplistic supposition exists when an analyst assumes that once single hazards are identified and hazard controls are applied, the job of the safety engineer is complete.
Alloco, Mike
core
FEBS Open Bio, EarlyView.TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao +10 more
wiley +1 more source
Chengshi guidao jiaotong yanjiu[Objective] At present, the regional rail transit system in China has entered a new stage of multi-network integrated development, and its operation and management also presents new characteristics of multi-level, multi-dimensional collaborative ...
LIU Yuxing +4 more
doaj +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
Blockchain-Driven Intelligent Scheme for IoT-Based Public Safety System beyond 5G Networks. [PDF]
Sensors (Basel), 2023 Rathod T +7 more
europepmc +1 more source