Results 41 to 50 of about 1,647,972 (256)

Indonesian Subtitling Translation Techniques in Muhsin and Mahasin Arabic Cartoons: A Descriptive Study Oriented to Newmark Theory

Tarling, 2022
The purpose of the study was to identify and describe the translation techniques, methods and ideologies used in translating Arabic cartoon subtitles Muhsin and Mahasin versions of the Youtube channel SFH channel and describe the quality of the ...
Muhammad Nur Kholis, Dika Ayu, Nadhifa N, Hafidah N, W Hakimmudin, M Luthfi   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Aligning Global Urban Planning Trends with Local Challenges: A Citizen-Centered Framework for Functional and Morphological Residential Zones in Port Said, Egypt [PDF]

JES: Journal of Engineering Sciences
Rapid urbanization is intensifying pressures on cities to improve livability and service provision, particularly in intermediate cities such as Port Said, Egypt.
Eman Farrag, Osama Abou El-Einen, Reem Abd El-raouf, Heba Ahmed   +3 more
doaj   +1 more source

Efficient Privacy-Preserving Scheme for Location Based Services in VANET System

IEEE Access, 2020
A Vehicular Ad-hoc Network (VANET) is a type of Mobile Ad-hoc Network (MANET) that is used to provide communications between nearby vehicles, and between vehicles and fixed infrastructure on the roadside.
Fifi Farouk, Yasmin Alkady, Rawya Rizk
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

DRL-Based Distributed Task Offloading Framework in Edge-Cloud Environment

IEEE Access
The Internet of Things (IoT) and real-time media streaming have increased due to the rapid development of wireless communication technologies and the enormous growth of computation and data transmission tasks.
Heba Nashaat, Walaa Hashem, Rawya Rizk, Radwa Attia   +3 more
doaj   +1 more source

From Deep LSTM-Based Gene Expression Modeling to microRNA Disease Association; hsa-miR-133b identified as a Potentially Functionally Conserved Tumor Suppressor Across Cancers [PDF]

Alfarama Journal of Basic & Applied Sciences
Background: Cancer remains a global health burden, and early, accurate diagnosis is vital. Most deep learning models focus on binary classification, with limited work on multiclass tasks. The roles of miRNAs in cancer have also been studied.
Loai Eletr, Hazem Elzeiny, Ganna Marey, Aalaa Amen, Abdelruhman Elshazly, Abdelrahman Elgebaly, Mostafa Herajy, Mohamed Hassan   +7 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source