Results 51 to 60 of about 876,603 (266)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

DRL-Based Distributed Task Offloading Framework in Edge-Cloud Environment

IEEE Access
The Internet of Things (IoT) and real-time media streaming have increased due to the rapid development of wireless communication technologies and the enormous growth of computation and data transmission tasks.
Heba Nashaat, Walaa Hashem, Rawya Rizk, Radwa Attia   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Entorhinal cortex atrophy score versus temporal lobe atrophy score in diagnosis and grading of Alzheimer’s disease

The Egyptian Journal of Radiology and Nuclear Medicine
Background Alzheimer’s disease (AD) is the commonest cause of dementia. Magnetic resonance imaging (MRI) is the commonest imaging modality used for differentiation AD dementia from other types of dementia.
Carmen Ali Zarad, Ali Abou Elmaaty, Khaled Abdel-Baki, Waleed Said Abo Shanab, Ahmed Aboughonaim, Mohamed Ahmed Hanora   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Assessment of Mentorship Competencies among Nurse Mentors at Port Said Healthcare Authority Hospitals [PDF]

Port Said Scientific Journal of Nursing
Background: Mentorship in nursing is a therapeutic relationship that exists between experienced nurses and less experienced nurses to help them gain more knowledge or experience in the profession.
Heba Hagrass, Sanaa Ibrahim, Rasha Anany, Heba El-Gazar   +3 more
doaj   +1 more source

Hybrid Desalination System Using Parabolic Trough Concentrator as a Heat Source [PDF]

Port Said Engineering Research Journal, 2016
This paper deals with the status of the new hybrid desalination methods which need more research like thermal vapor compression and direct contact membrane distillation system.
asmaa Rashed, Amany Saif, Morsy Shatat, A. Mohamed   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

MANSÛRÎZÂDE SAİD’İN KLASİK FIKIHÇILARA YÖNELTTİĞİ BAZI ELEŞTİRİLER

Cumhuriyet Üniversitesi İlahiyat Fakültesi Dergisi, 2001
İslam hukuku ya da klasik ifadesiyle fıkıh, İslam toplumlarının hayat bilgisi ve tarzı, diğer bir ifadeyle müslüman toplumların kimliği, geleneği ve bu toplumlardaki hukuk kültürüdür1 .
ABDULLAH KAHRAMAN
doaj