Results 71 to 80 of about 9,495 (265)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Voorbeeldlevens van toen en nu
Neerlandica WratislaviensiaWonderbaarlijke levens. Patronen in heiligenlevens by Ludo Jongen offers a richly illustrated and accessible exploration of medieval hagiography. Drawing on decades of research, Jongen examines recurring patterns in saints’ lives and their enduring ...
Małgorzata Dowlaszewicz
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Lietuvos Istorijos StudijosThe article examines the 20th-century histories of the veneration of Saint Casimir and Saint Josaphat Kuntsevych, seeking to answer the following questions: Does the development of these cases correlate with tendencies to instrumentalize national ...
Arūnas Streikus
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Saint-Projet - Saint-Constant [PDF]
ADLFI. Archéologie de la France - Informations, 2009 Identifiant de l'operation archeologique : 203946 Date de l'operation : 2009 (EX) Lors du suivi archeologique des travaux du contournement de La Rochefoucauld, une equipe de l'INRAP a decouvert pres de « La Becasse » les vestiges d'une occupation medievale. Silos, arases de bâtiment et fosses sont dates du Moyen Âge classique.
openaire +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source