Lower resting‐state phasic locus coeruleus activity is associated with cortical tau accumulation and cognitive decline in preclinical Alzheimer’s disease [PDF]
Abstract Background The brainstem noradrenergic locus coeruleus (LC) is among the earliest regions to accumulate Alzheimer's disease (AD)‐related hyperphosphorylated tau. Lower novelty‐related LC activity in older cognitively healthy individuals has been related to greater entorhinal (EC) tau deposition and steeper memory decline.
Prokopiou P +7 more
europepmc +3 more sources
Milk Modulates the Gastrointestinal Stability of Tick-Borne Encephalitis Virus: Implications for Alimentary Transmission. [PDF]
ABSTRACT Tick‐borne encephalitis virus (TBEV) can be transmitted alimentarily through contaminated dairy products, yet the mechanisms by which the virus survives the digestive tract remain poorly understood. In this study, we investigated the stability of TBEV in milk under simulated gastrointestinal conditions.
Machacek M +3 more
europepmc +2 more sources
Gray to white matter signal ratio (GWR) as a novel MRI‐based biomarker of longitudinal cognitive decline in older adults with and without amyloid pathology [PDF]
Abstract Background Microstructural properties of cortical gray matter are disrupted early in Alzheimer’s disease (AD), even before the onset of cognitive impairment. We and others have demonstrated across the symptomatic spectrum of AD that the gray to white matter signal intensity ratio (GWR), which quantifies the signal contrast between these tissue
Loxton C +3 more
europepmc +2 more sources
Resting state EEG Theta rhythms in healthy aging and Alzheimer's disease [PDF]
Abstract Background Healthy aging and cognitive decline in Alzheimer's Disease (AD) and its precursor, Mild Cognitive Impairment (MCI), are linked to changes in resting‐state EEG power spectral density (PSD). Theta band (3‐7 Hz) power decreases with normal aging but increases with cognitive decline.
Meghdadi A +8 more
europepmc +2 more sources
Impact of white matter lesions on clinical progression of Alzheimer's disease when accounting for regional neurodegeneration [PDF]
Abstract Background Alzheimer's disease (AD) is defined by a distinct neuropathological signature, yet symptom severity can vary among individuals with similar levels of pathology. For example, some individuals with the same degree of AD pathology exhibit severe dementia, while others retain relatively higher cognitive function, a phenomenon referred ...
Paruchuri N, Jacoby J, Salat D.
europepmc +2 more sources
Age-Related Alterations in Hippocampal Microstructure Quantified Using High-Gradient Diffusion MRI (dMRI) in an Unfolded Hippocampal Space. [PDF]
Using high‐gradient diffusion MRI with the SANDI model and HippUnfold for fine‐scale analysis, we detected localized hippocampal aging changes beyond volumetric/thickness reductions. Subiculum and dentate gyrus exhibit significantly reduced soma density/size and increased extracellular space, highlighting subtle microstructural alterations critical for
Ma Y +12 more
europepmc +2 more sources
Kur’an-ı Kerimdeki Manaları ile “Salât” Sözcüğü [PDF]
Kur’an’da salât kelimesinin çeşitli kullanımları bulunmakta ve bu kullanımlardan her biri kendi içinde birçok gizem içermektedir. Allah-u Teala önemine binaen, salât kelime- sini Kur’an’da yüz dolayında ayette zikretmiştir.
Hasan Akreş
doaj +1 more source
Osmanlı Kültüründe Salât-u Selâm Mûsikîsi Geleneği [PDF]
Arapça’da dua ve namaz sözcük anlamlarına karşılık olarak gelmekte olansalât, –ki dini mûsikî formlarında salâ olarak telaffuz edilmektedir- Türk dinmûsikîsi formundaki özel anlamı bakımından, Hz.
Uğur Alkan
doaj +1 more source
Arapçada hayır dua anlamına gelen pek çok kavramı ihtiva eden salâtı kısaca; “Hz. Muhammed’e (s.a.v.) merhamet, mağfiret, feyz ü bereket vs. hayırlar ihsan etmesini Allah’tan (c.c.) dilemek” şeklinde tanımlamak mümkündür.
Yavuz Demirtaş
doaj +1 more source
Leveraging a Smartwatch for Activity Recognition in Salat
Salat, the most important worship of Muslims and the second pillar of Islam, is an integral part of the Muslim community. Being a complex activity, Salat involves a series of steady and transitional activities to be performed in a specific sequence.
Ishrat Jahan +4 more
doaj +1 more source

