Results 21 to 30 of about 119,482 (306)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

open access: yesFEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell   +2 more
wiley   +1 more source

Pedro Romero, el artesano: trabajo, raza y diferenciación social en Cartagena de Indias a finales del dominio colonial

open access: yesHistoria Crítica, 2016
This article studies the questions of work, race and social differentiation among the artisan class of the New Kingdom of Granada towards the end of the colonial period, through the labor activities of Pedro Romero, an emblematic artisan of Cartagena de ...
Sergio Paolo Solano D.
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Librarian in the new salary system of civil servants

open access: yesKnjižnica, 2008
Salary System in the Public Sector Act (Uradni list RS, No. 95/07 consolidated text, and 17/08) regulates the salary system for civil servants anew. Until now, posts indifferent workplaces and under the competence of diferrent ministries have been valued
Sabina Fras Popović
doaj   +1 more source

Localization of salaries of public sector employees in Iraq and its role in enhancing financial inclusion in banks

open access: yesمجلة الدراسات الاقتصادية والادارية, 2023
The aim of this paper is to determine the influence of the accounting information system on the localization of salaries on enhancing financial inclusion in banks. This study utilises the data from the content analysis of the 37 banks.
Zainab Hamid Kateh   +2 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

open access: yesMolecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira   +7 more
wiley   +1 more source

The Genoese consuls of Tana (Azak) according to the tax registers from the State Archives of Genoa: the chronology of consulates (1449–1475)

open access: yesЗолотоордынское обозрение
Purpose of the study: The Genoese trading station – Tana, which existed on the territory of the Golden Horde and then the Crimean Khanate, was closely connected with the center of Genoese Gazaria – Caffa and served as an important transshipment point in ...
Karpov S.P.
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

More money does not mean more Big Macs – Analysis of physicians’ purchasing power in European countries

open access: yesEkonomski Vjesnik
Purpose: One of the major determinants of the well-being of citizens is the purchasing power of their income. Recently, there has been a significant outmigration of physicians from countries with low GDP per capita to those with high GDP per capita. This
David Jutrić   +2 more
doaj   +1 more source

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