Results 241 to 250 of about 889,102 (330)

Testosterone Delays Bone Microstructural Destruction via Osteoblast‐Androgen Receptor‐Mediated Upregulation of Tenascin‐C

Advanced Science, EarlyView.
This study reveals that Testosterone–Androgen Receptor signaling delays elderly male bone destruction by upregulation of the osteoblastic extracellular tenascin‐C (TNC). The osteoprotective effect of fibrinogen C‐terminus of TNC is demonstrated in male osteoporotic mice model that osteoblast‐specific Ar‐knockout, potentially via inhibition of ...
Yong Xie, Meng Pan, Zeyuan Zhang, Licheng Zhang, Haotian Liu, Xia Wang, William W Lu, Peifu Tang, Wei Ge   +8 more
wiley   +1 more source

Asking an AI for salary negotiation advice is a matter of concern: Controlled experimental perturbation of ChatGPT for protected and non-protected group discrimination on a contextual task with no clear ground truth answers. [PDF]

PLoS One
Geiger RS, O'Sullivan F, Wang E, Lo J.
europepmc   +1 more source

FLASH Irradiation Modulates Immune Responses and Accelerates Lung Recovery: A Single‐Cell Perspective

Advanced Science, EarlyView.
Single‐cell RNA sequencing reveals distinct immune responses to FLASH versus conventional dose rate irradiation in early radiation‐induced lung injury. FLASH irradiation reduces Ccrl2⁺ neutrophil infiltration, activates CD4⁺ CD40L⁺ Th cells, restrains pro‐inflammatory Mefv⁺ monocytes, and enhances epithelial repair via TGF‐β signaling, underscoring its
Hao Lu, Menghua Li, Cheng Quan, Caihui Li, Dawei Li, Zhihui Li, Jing Xu, Lihui Zhang, Qixiang Liu, Guofu Dong, Changzhen Wang   +10 more
wiley   +1 more source

Laser‐Induced Co‐Doped FePS3 with Massively Phosphorus Sulfur Vacancies Nanosheet for Efficient and Highly Stable Electrocatalytic Oxygen Reaction

Advanced Science, EarlyView.
DFT‐guided defect engineering in 2D FePS3 reveals S/P vacancies Co‐doped and exposed Fe sites synergistically enhance OER performance. Laser‐ablation‐induced (Fe0.53Co0.46)PS3 exhibits excellent OER performance (288 mV overpotential, 58.3 mV dec−1 Tafel slope) and outstanding stability (138 h at 10 mA cm−2, 27h at 100 mA cm−2).
Ruiqi Xu, Guoshuai Fu, Weimi Ding, Yifan Li, Guowei Yang, Peng Yu, Shuang Li, Pu Liu   +7 more
wiley   +1 more source

Development of a job satisfaction measure for clinical research professionals: A mixed methods approach. [PDF]

J Clin Transl Sci
Knapke JM, Kues J, Harris SK, Snyder DC, Freel SA, Pallerla H, Fritter J, Mendell A, Jones CT.   +8 more
europepmc   +1 more source

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

Did the reform of the public hospitals' pay system increase the physicians' pay in China? A cross-sectional study. [PDF]

Front Public Health
Zhao Y, Zhou Z, Zhai X, Liu G, Wang Z, Deng Q.   +5 more
europepmc   +1 more source

Transforming the Poison Effects of Water Vapor into Benefits Over Adjustable Dual Acid Sites for Stable Plasma‐Catalysis

Advanced Science, EarlyView.
YxMnyOx+2y catalyst provides dual active sites of Lewis acid (Y3+) and Mn for the co‐adsorption of H2O and O3, and the fast dissociation of adsorbed H2O to surface *OH. Then, a newly OH‐accompanied pathway for O3 decomposition is formed, transforming H2O to active ·OH radical, with the assistance of high energy electrons in the plasma.
Si Chen, Sibo Zhang, Lu Fang, Yan Yang, Chenyuan Zhu, Xinyi Dai, Zhengjun Gong, Fan Dong   +7 more
wiley   +1 more source

Quantitative Electron Beam‐Single Atom Interactions Enabled by Sub‐20‐pm Precision Targeting

Advanced Science, EarlyView.
Atomic lock‐on (ALO) is a rapid, low‐dose in situ technique in scanning transmission electron microscopy (STEM) that achieves sub‐20 picometer (pm) beam positioning. A sparse annular scan collects positional information while avoiding irradiation of the target site.
Kevin M. Roccapriore, Frances M. Ross, Julian Klein   +2 more
wiley   +1 more source

General Screening Rules and Segmented Optimization Strategy for Efficient Thermoelectric Devices Validated by Mg3(Sb,Bi)2/Bi0.5Sb1.5Te3‐GeTe Module

Advanced Science, EarlyView.
By leveraging the materials' compatibility, optimized matching relationships are established to enhance the performance of segmented thermoelectric devices. To validate this approach, a segmented thermoelectric generator is fabricated incorporating n‐type Mg3(Sb,Bi)2 and p‐type Bi0.5Sb1.5Te3‐GeTe.
Kai‐Yu Yang, Xiaoyuan Li, Yuanxin Jiang, Liangliang Wang, Kai Guo, Lei Miao, Junliang Chen, Jiye Zhang, Lin Li, Yusong Du, Guang‐Hui Rao, Jun Luo, Jing‐Tai Zhao   +12 more
wiley   +1 more source