Results 51 to 60 of about 8,400 (231)

Real‐World‐Daten zu Tirbanibulin bei aktinischer Keratose in Deutschland ‐ Prospektive multizentrische nichtinterventionelle KLIR‐Studie

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 24, Issue 2, Page 186-194, February 2026.
Zusammenfassung Hintergrund In dieser nichtinterventionellen Studie wurde die Wirksamkeit und Sicherheit von Tirbanibulin, einem zugelassenen topischen Medikament zur Behandlung aktinischer Keratosen (AK), untersucht. Patienten und Methodik Die prospektive nichtinterventionelle Studie wurde an 58 dermatologischen Kliniken und Praxen in Deutschland ...
Markus V. Heppt, Ina Hadshiew, Afra Kempf, Antje Melzer, Carola Berking   +4 more
wiley   +1 more source

Salvianolic acid B protects against lipopolysaccharide-induced behavioral deficits and neuroinflammatory response: involvement of autophagy and NLRP3 inflammasome

Journal of Neuroinflammation, 2017
Background The NLRP3 inflammasome activation and neuroinflammation are known to be involved in the pathology of depression, whereas autophagy has multiple effects on immunity, which is partly mediated by the regulation of inflammasome and clearance of ...
Pei Jiang, Yujin Guo, Ruili Dang, Mengqi Yang, Dehua Liao, Huande Li, Zhen Sun, Qingyan Feng, Pengfei Xu   +8 more
doaj   +1 more source

Agonist-Promoted Phosphorylation and Internalization of the Kappa Opioid Receptor in Mouse Brains: Lack of Connection With Conditioned Place Aversion

Frontiers in Pharmacology, 2022
Selective kappa opioid receptor (KOR) agonists are promising antipruritic agents and analgesics. However, clinical development of KOR agonists has been limited by side effects, including psychotomimetic effects, dysphoria, and sedation, except for ...
Chongguang Chen, Peng Huang, Kathryn Bland, Mengchu Li, Yan Zhang, Lee-Yuan Liu-Chen   +5 more
doaj   +1 more source

All Nanozyme‐Based Cascade Reactions for Biomedical Applications: from Self‐Cascading Nanozyme to Immobilized Cascade Nanozyme

Advanced Science, Volume 13, Issue 6, 30 January 2026.
This review introduces the development and classification of all‐nanozyme cascade reaction systems, highlighting mechanistic insights and research methods for understanding catalytic features and design principles. It provides detailed classifications, surveys recent applications in biosensing and therapy, and discusses the challenges that all‐nanozyme
Caixia Zhu, Congcong Jiang, Hian Kee Lee, Yuanjian Zhang, Sheng Tang   +4 more
wiley   +1 more source

Validation of an automated enzyme immunoassay for interleukin-6 for routine clinical use [PDF]

, 1998
Serum levels of Interleukin-6 (IL-6), a proinflammatory cytokine, are increased in early stages of inflammatory diseases such as infection and sepsis. Assay systems which permit its measurement within a few hours and as a single measurement have not been
Cremer, Peter, Dehart, Isabelle, Fraunberger, Peter, Holler, Ernst, Nagel, Dorothea, Pfeiffer, Matthias, Seidel, Dietrich, Thein, Michael, Walli, Autar K.   +8 more
core   +1 more source

Sleeping Schedule-Aware Local Broadcast in Wireless Sensor Networks

International Journal of Distributed Sensor Networks, 2013
Broadcast is widely used in applications in wireless sensor networks (WSNs). In the last decade, the broadcast problem in WSNs has been well studied. However, few of existing broadcasting strategies have considered the scenarios with sleeping schedules ...
Jue Hong, Zhuo Li, Dianjie Lu, Sanglu Lu
doaj   +1 more source

Salvianolic Acid B Ameliorates Cognitive Deficits Through IGF-1/Akt Pathway in Rats with Vascular Dementia

Cellular Physiology and Biochemistry, 2017
BackgroundAims: Salvianolic acid B (SalB) is a natural polyphenolic compound enriched in Salvia miltiorrhiza Bunge. Our study was designed to explore the role of Sal B on cognitive impairment in vascular dementia (VD) model rats, as well as its possible ...
Xiaowei Ma, Weiwei Xu, Zhongxia Zhang, Na Liu, Jie Yang, Mingwei Wang, Yanyong Wang   +6 more
doaj   +1 more source

Reconstruction of a Genome-Scale Metabolic Model of Streptomyces albus J1074: Improved Engineering Strategies in Natural Product Synthesis

Metabolites, 2021
Streptomyces albus J1074 is recognized as an effective host for heterologous production of natural products. Its fast growth and efficient genetic toolbox due to a naturally minimized genome have contributed towards its advantage in expressing ...
Cheewin Kittikunapong, Suhui Ye, Patricia Magadán-Corpas, Álvaro Pérez-Valero, Claudio J. Villar, Felipe Lombó, Eduard J. Kerkhoven   +6 more
doaj   +1 more source

Rubber genetics and breeding at Cirad-France Country report of activities from 2007 to 2011 (AGAP research unit) [PDF]

, 2011
In Cirad and the research unit " AGAP ", the two groups EGV (Marc Seguin et al.) and BURST (Pascal Montoro et al.) work on rubber genetics and molecular physiology respectively.
Clément-Demange, André, Garcia, Dominique, Le Guen, Vincent, Montoro, Pascal, Pujade-Renaud, Valérie, Seguin, Marc   +5 more
core  

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

Cell Proliferation, Volume 58, Issue 9, September 2025.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou, Dongwei Liu, Zuishuang Guo, Cien Wei, Fengyu Cao, Yue Xu, Qi Feng, Fengxun Liu   +7 more
wiley   +1 more source