Results 101 to 110 of about 1,306,008 (359)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Performance of Electrical Spectroscopy using a Resper Probe to Measure the Salinity and Water Content of Concrete or Terrestrial Soil [PDF]

, 2011
This paper discusses the performance of electrical spectroscopy using a RESPER probe to measure the salinity s and volumetric content {\theta}W of the water in concrete or terrestrial soil.
Settimi, A.
core   +4 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Prolonged alkali water irrigation: impacts of treatment strategies on soil health and microbial dynamics

Ecological Processes
Background The extent of natural salt-laden groundwaters used for irrigation is increasing worldwide, which is a fast-emerging threat to agroecosystems and global food security.
Kirti Yadav, Awtar Singh, Neeraj K. Aggarwal, Gajender Yadav, Nirmalendu Basak, Ajay Kumar Bhardwaj, Rajender Kumar Yadav   +6 more
doaj   +1 more source

Standardization of the fourier transform near-infrared reflectance spectroscopy for estimation of some oil quality parameters in mustard (Brassica spp.)

Plant, Soil and Environment, 2013
The possibility of the application of the fourier transform near-infrared reflectance spectroscopy (NIRS) to the analysis of the selected quality parameters in the mustard oil was followed to determine oil, protein, erucic acid and crude fibre content at
J. Singh, P.C. Sharma, S.K. Sharma, A. Kumar   +3 more
doaj   +1 more source

Symptomatic absorption of normal saline during transurethral resection of the prostate: a case report [PDF]

, 2022
Naomi Okuma, Hideki Hino, Madoka Kuroki, Tadashi Matsuura, Takashi Mori   +4 more
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Offsetting with Salinity Credits: An Alternative to Irrigation Zoning [PDF]

Irrigation induced salinity is a serious problem in many countries around the world. In Australia, this type of salinity is most pronounced in the valley of the River Murray in South Australia.
Ancev, Tihomir, Spencer, Thomas
core   +1 more source

Overview of the Nordic Seas CARINA data and salinity measurements [PDF]

, 2009
Water column data of carbon and carbon relevant hydrographic and hydrochemical parameters from 188 previously non-publicly available cruises in the Arctic, Atlantic, and Southern Ocean have been retrieved and merged into a new database: CARINA (CARbon IN
A. Kozyr, A. M. Omar, A. Olsen, B. Pfeil, C. Schirnick, D. W. R. Wallace, E. Falck, E. Jeansson, F. Rey, I. Skjelvan, J. Blindheim, J. L. Bullister, J. Olafsson, K. A. Olsson, L. G. Anderson, R. G. J. Bellerby, R. M. Key, S. Jutterström, S. van Heuven, T. Johannessen, T. Tanhua, X. Lin   +21 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source