Results 101 to 110 of about 229,845 (322)
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Performance of edible cactus (Opuntiaficus-indica) in saline environments
The Indian Journal of Agricultural Sciences, 2014 Edible cactus [Opuntiaficus-indica (L.) Mill.] has been used as fruit, vegetable, forage and wide range of commercial purposes in arid regions. It has high efficiency to produce biomass per unit water use due to specialized photosynthetic mechanism ...
GAJENDER GAJENDER +4 more
doaj +1 more source
Enstrophy and Ergodicity of Gravity Currents [PDF]
arXiv, 2004 We study a coupled deterministic system of vorticity evolution and salinity transport equations, with spatially correlated white noise on the boundary. This system may be considered as a model for gravity currents in oceanic fluids. The noise is due to uncertainty in salinity flux on fluid boundary.
arxiv
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
Buoyancy-driven flow regimes for a melting vertical ice cylinder in saline water [PDF]
arXivThe presence of salt in seawater significantly affects the melt rate and morphological evolution of ice. This study investigates the melting process of a vertical cylinder in saline water using a combination of laboratory experiments and direct numerical simulations.
arxiv
Salinity tolerance in plants: attempts to manipulate ion transport [PDF]
arXiv, 2014 Ion transport is the major determining factor of salinity tolerance in plants. A simple scheme of a plant cell with ion fluxes provides basic understanding of ion transport and the corresponding changes of ion concentrations under salinity. The review describes in detail basic principles of ion transport for a plant cell, introduces set of transporters
arxiv
Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry
Molecular Oncology, EarlyView.Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson +11 more
wiley +1 more source