Results 81 to 90 of about 369,735 (304)
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Plant, Soil and Environment, 2013 The possibility of the application of the fourier transform near-infrared reflectance spectroscopy (NIRS) to the analysis of the selected quality parameters in the mustard oil was followed to determine oil, protein, erucic acid and crude fibre content at
J. Singh +3 more
doaj +1 more source
Dryland Salinity: Spatial Impacts and Farmers' Options [PDF]
The salinisation of farmland in Australia is a major natural resource management problem. Over the next 20 years a further 1.1 million hectares of broadacre farmland is predicted to become salt-affected.
Kingwell, Ross S.
core
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Rethinking the externality issue for dryland salinity in Western Australia [PDF]
Dryland salinity has been conceived of as a problem involving massive off‐site impacts and therefore requiring coordinated action to ensure that land managers reduce those off‐site impacts.
Pannell, David J. +2 more
core
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Efficiency Policies for Salinity Management: Preliminary Research from a Spatial and Dynamic Metamodel [PDF]
Dryland salinity, as an externality, has an impact on various public assets, including roads, biodiversity and public water supplies. This has been seen as an important justification for government to take action and internalise the pollution.
Pannell, David J. +2 more
core
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source
Salinity in Water Markets : An ExperimentalInvestigation of the Sunraysia Salinity Levy, Victoria [PDF]
Irrigation can have a significant negative impact on the environment. Irrigation impacts contribute a significant portion to the estimated forty six million dollar cost per annum of salinity in the Murray River, Australia.
L. Gangadharan, C. Duke
core