Results 81 to 90 of about 292,464 (315)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Major faults and the development of dryland salinity in the western wheatbelt of Western Australia
, 1998 Dryland salinity poses a major threat to agricultural production in the wheatbelt of Western Australia and much time and effort is expended on understanding the mechanisms which cause it and on developing techniques to halt or reverse its development ...
C. J. Clarke +11 more
core
The Indian Journal of Agricultural Sciences, 2018 We studied the effects of sodic irrigation on growth, physiological parameters and mineral partitioning in Zizyphus rotundifolia (ZR) and Z. spina-christi (ZS) seedlings used as rootstocks for Indian jujube scion cultivars.
ANSHUMAN SINGH +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The influence of salinity on various life stages of Ruppia tuberosa and implications for its distribution in the Coorong, South Australia. [PDF]
, 2014 Despite the obvious decline in the distribution of Ruppia in the Coorong, there have been few extensive studies investigating the factors that control the distribution of this genus.
Kim, Dae Heui
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Reducing the cost of South Australia of achieving agreed salinity targets in the River Murray. [PDF]
Past irrigation development has lead to rising salt loads in the River Murray and its floodplains, and reduced river flows. Even in the absence of any further development, river and floodplain salt loading as the result of this irrigation is anticipated ...
Jeffery Connor
core
, 2002 A few wheat varieties including two Japanese wheat varieties were evaluated for their salt tolerance at seeding stage, their behavior to increasing salinity levels and role of Na exclusion capacity in salt tolerance mechanisms.
Adachi, Tadashi +2 more
core +1 more source