The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Members of the Solanaceae family, such as tomatoes (Solanum lycopersicum), eggplants (Solanum melongena L.), and peppers (Capsicum chinense L.), are moderately sensitive to salinity, which could limit their production, especially under future water ...
Ray G. Anderson +5 more
doaj +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Dryland salinity, coordinating action and economic policy: a role for contracts?
The problem of addressing dryland salinity at a landscape is considered in the context of using economic incentives to encourage change in land use by individual landholders to adopt salinity mitigating actions where a public asset of significant value ...
Harvey, Sallyann
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Farmers' perceptions on salinity and sodicity: A case study into farmers' knowledge of salinity and sodicity, and their strategies and practices to deal with salinity and sodicity in their farm systems [PDF]
Farmer managed irrigation systems / Salinity / Sodic soils / Sustainable agriculture / Farmers' attitudes / Case studies / Water quality / Pakistan / Punjab / Chishtian Sub ...
Kielen, N.
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Salinity of irrigation water in the Philippi farming area of the cape flats, Cape Town, South Africa [PDF]
Magister Scientiae - MScThis research investigated the nature, source and the spatial variation of the salinity of the water used for irrigation in the urban farming area of Philippi, which lies in the Cape Flats region of the Cape Town Metropolitan Area,
Aza-Gnandji, Cocou Davis Ruben
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Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
Landscape scale regolith variation in hydraulic parameters and its effect on dryland salinity
This paper brings together the results of research into the impact that major faults have on dryland salinity, and the development of revegetation treatments in the wheatbelt of Western Australia.
George, R. +4 more
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Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Development and validation of a DIY profiling float for indirect determination of salinity
Ocean salinity, a measure of salt concentration in seawater, is a key variable influencing water density and controls important processes like mixing and stratification.
Flaim, Caleb
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