Results 41 to 50 of about 369,735 (304)

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Multivariate analysis of phenotypic diversity of rice (Oryza sativa) germplasm in North-West India

The Indian Journal of Agricultural Sciences, 2014
Genetic diversity of 2142 accessions of rice (Oryza sativa L.) from India based on the multivariate analysis for 10 agro-morphological traits was evaluated using augmented experimental design at CSSRI, Karnal, Haryana, in kharif 2010-11. In all, a total
S K SHARMA, JOGENDRA SINGH, MAHESH S CHAUHAN, S L KRISHNAMURTHY   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Understanding the salt overly sensitive pathway in Prunus: Identification and characterization of NHX, CIPK, and CBL genes

The Plant Genome
Salinity is a major abiotic stress factor that can significantly impact crop growth, and productivity. In response to salt stress, the plant Salt Overly Sensitive (SOS) signaling pathway regulates the homeostasis of intracellular sodium ion concentration.
Biswa R. Acharya, Chaoyang Zhao, Lorenso Antonio Rodriguez Reyes, Jorge F. S. Ferreira, Devinder Sandhu   +4 more
doaj   +1 more source

Elemental toxicities – adaptive traits governing waterlogging tolerance in wheat (Triticum aestivum) under sodic soils

The Indian Journal of Agricultural Sciences, 2020
Wheat (Triticum aestivum L.) is one of the most intolerant crops to soil waterlogging, so to evaluate the response of 10 wheat varieties to waterlogging stress under sodic soils, a pot experiment was conducted during 2011-12, 2012-13 and 2014-15 at ICAR ...
NEERAJ KULSHRESHTHA, ASHWANI KUMAR, K R K PRASAD, MONIKA SINGH, RAJESH KUMAR, NIRMALENDU BASAK, N P S YADUVANSHI, P C SHARMA, S K SHARMA   +8 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Elucidating morphogenic and physiological traits of rice with nitrogen substitution through nano-nitrogen under salt stress conditions

BMC Plant Biology
Background Sustainable crop production along with best nutrient use efficiency is the key indicator of smart agriculture. Foliar application of plant nutrients can complement soil fertilization with improved nutrient uptake, translocation and utilization.
Ashwani Kumar, Parvender Sheoran, Naresh Kumar, Sunita Devi, Arvind Kumar, Kapil Malik, Manu Rani, Ajay Kumar Bhardwaj, Anita Mann   +8 more
doaj   +1 more source

Comparative genomics reveals the molecular mechanism of salt adaptation for zoysiagrasses

BMC Plant Biology, 2022
Background Zoysiagrass (Zoysia spp.) is a warm-season turfgrass. It is widely used as turfgrasses throughout the world, offers good turf qualities, including salt tolerance, resistance to drought and heat.
Wei Wang, An Shao, Xiao Xu, Shugao Fan, Jinmin Fu   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Alfalfa MsSOS2 confers salinity tolerance by promoting lateral root growth and regulating Na+/K+ homeostasis

Scientific Reports
Salinity is a major abiotic stress limiting plant productivity. The Salt Overly Sensitive (SOS) pathway, comprising SOS1, SOS2, and SOS3, is central to ion homeostasis under salt stress. While the pathway has been extensively studied in model plants, its
Biswa R. Acharya, Lorenso A. R. Reyes, Lipsa Mishra, Jorge F. S. Ferreira, Todd H. Skaggs, Devinder Sandhu   +5 more
doaj   +1 more source