Results 51 to 60 of about 292,464 (315)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Temporal variations in morpho-physiology of sandalwood and gene expression analysis revealed Shisham as host preference under water deficit and salinity stress

BMC Plant Biology
Background Sandalwood (Santalum album L.), a valuable aromatic tree species, faces significant growth and physiological challenges under abiotic stresses like water deficit and salinity, especially when both stressors are present. Host plant associations
Ashwani Kumar, Aarju Sharma, Shruti Kaushik, Antim Kundu, Pooja Dhansu, Kamlesh Verma, Raj Kumar, Abdulaziz Abdullah Alsahli, Parvender Sheoran   +8 more
doaj   +1 more source

A multi-dimensional analysis of integrated farming system in salt-affected ecologies

The Indian Journal of Agricultural Sciences
The horizontal expansion of the arable areas seems infeasible with dwindling natural resources and declining the average size of landholdings. For harnessing the economic, environmental and social benefits of vertical expansion, the Integrated Farming ...
RAJKUMAR, SURESH KUMAR, RAM KISHOR FAGODIYA, AWTAR SINGH, PARVENDER SHEORAN, GAJENDER YADAV, NIRMAL SINGH, SUBHASIS MANDAL, R K YADAV   +8 more
doaj   +1 more source

Biochemical changes in guava (Psidium guajava) cv. Allahabad Safeda fruits as a function of maturity stages

The Indian Journal of Agricultural Sciences, 2016
The effects of maturity stage and harvesting season were investigated on fruit quality attributes like total antioxidant activity (DPPH), total flavanoids, total phenolics, H2O2 scavenging activity and ascorbic acid content in fruits of guava (Psidium ...
RAJKUMAR RAJKUMAR, GURPREET KAUR, ANITA MANN, CHARU LATA, ANSHUMAN SINGH, ASHWANI KUMAR   +5 more
doaj   +1 more source

de novo transcriptomic profiling of differentially expressed genes in grass halophyte Urochondra setulosa under high salinity

Scientific Reports, 2021
Soil salinity is one of the major limiting factors for crop productivity across the world. Halophytes have recently been a source of attraction for exploring the survival and tolerance mechanisms at extreme saline conditions.
Anita Mann, Naresh Kumar, Ashwani Kumar, Charu Lata, Arvind Kumar, Babu Lal Meena, Dwijesh Mishra, Monendra Grover, Sonam Gaba, C. Parameswaran, Nitin Mantri   +10 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Impact of water deficit (salt and drought) stress on physiological, biochemical and yield attributes on wheat (Triticum aestivum) varieties

The Indian Journal of Agricultural Sciences, 2018
This investigation was carried out to assess the combined effect of salt stress and drought on physiological and biochemical traits in wheat (Triticum aestivum L.) varieties so as to deduce the probable mechanism of stress tolerance in these varieties ...
ASHWANI KUMAR, SURINDER KUMAR SHARMA, CHARU LATA, RITU DEVI, NEERAJ KULSHRESTHA, S L KRISHNAMURTHY, KAILASH SINGH, RAJENDER KUMAR YADAV   +7 more
doaj   +1 more source

Involvement of cell cycle and ion transferring in the salt stress responses of alfalfa varieties at different development stages

BMC Plant Biology, 2023
Background Alfalfa (Medicago sativa) is the worldwide major feed crop for livestock. However, forage quality and productivity are reduced by salt stress, which is a common issue in alfalfa-growing regions.
YanLing Yin, ShuGao Fan, Shuang Li, Erick Amombo, JinMin Fu   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source