Results 81 to 90 of about 947,047 (350)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Mechanism of Salinity Tolerance in Plants: Physiological, Biochemical, and Molecular Characterization

International Journal of Genomics, 2014
Salinity is a major abiotic stress limiting growth and productivity of plants in many areas of the world due to increasing use of poor quality of water for irrigation and soil salinization.
Bhaskar Gupta, Bingru Huang
semanticscholar   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Strategic Switching from Conventional Urea to Nano-Urea for Sustaining the Rice–Wheat Cropping System

Plants
In the face of declining crop yields, inefficient fertilizer usage, nutrient depletion, and limited water availability, the efficiency of conventional NPK fertilizers is a critical issue in India.
Ashwani Kumar, Parvender Sheoran, Sunita Devi, Naresh Kumar, Kapil Malik, Manu Rani, Arvind Kumar, Pooja Dhansu, Shruti Kaushik, Ajay Kumar Bhardwaj, Anita Mann, Rajender Kumar Yadav   +11 more
doaj   +1 more source

Standardization of the fourier transform near-infrared reflectance spectroscopy for estimation of some oil quality parameters in mustard (Brassica spp.)

Plant, Soil and Environment, 2013
The possibility of the application of the fourier transform near-infrared reflectance spectroscopy (NIRS) to the analysis of the selected quality parameters in the mustard oil was followed to determine oil, protein, erucic acid and crude fibre content at
J. Singh, P.C. Sharma, S.K. Sharma, A. Kumar   +3 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Salinity and crop yield.

Plant biology, 2018
Thirty crop species provide 90% of our food, most of which display severe yield losses under moderate salinity. Securing and augmenting agricultural yield in times of global warming and population increase is urgent and should, aside from ameliorating ...
C. Zörb, C. Geilfus, Karl-Josef Dietz
semanticscholar   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Transitioning From Soil‐Based to Soil‐Foliar Hybrid Application for Nitrogen Fertilizers Offers Energy‐Saving and Use‐Efficiency Benefits

Food and Energy Security
Nitrogen (N) is the most important nutrient for crop plants to achieve their yield potential, yet it is also recognized as a major pollutant of the environment due to often‐excessive N‐fertilizer use.
Ajay Kumar Bhardwaj, Kapil Malik, Manu Rani, Ashwani Kumar, Sunita Devi, Naresh Kumar, Raj Kumar, Anita Mann, Parvender Sheoran, Uttam Kumar Mandal, Rajender Kumar Yadav   +10 more
doaj   +1 more source

Impact of pressmud application in reclamation of high RSC irrigation water induced soil sodification and sustaining rice (Oryza sativa) - wheat (Triticum aestivum) production in Indo-Gangetic Plains

The Indian Journal of Agricultural Sciences, 2020
Farmers mostly prefer mineral gypsum as reclamation ameliorant for sodic soils. Timely availability of quality product many a times hampers the pace of reclamation process impairing crops productivity to a greater extent.
PARVENDER SHEORAN, ARVIND KUMAR, ASHWANI KUMAR, R RAJU, RAMAN SHARMA, KAILASH PARJAPAT, ARIJIT BARMAN, RANJAY K SINGH, SATYENDRA KUMAR, P C SHARMA, V P CHAHAL, A K SINGH   +11 more
doaj   +1 more source