Results 41 to 50 of about 30,327 (259)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Model for evaluating the electric power output of Pressure Retarded Osmosis generation plants

International Marine Energy Journal, 2020
In this work a mathematical model is assembled to evaluate the electric complex power and electric current output of pressure retarded osmosis (PRO)- based generation plants.
Mario Llamas-Rivas, Alejandro Pizano-Martínez, Claudio R. Fuerte-Esquivel, Luis R. Merchan-Villalba, Víctor J. Gutiérrez-Martínez   +4 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Ice blocks melting into a salinity gradient [PDF]

Journal of Fluid Mechanics, 1980
In our previous qualitative paper, it was shown that when a vertical ice surface melts into a stable salinity gradient, the melt water spreads out into the interior in a series of nearly horizontal layers. The experiments reported here are aimed at quantifying this effect, which could be of some importance in the application to melting icebergs ...
Herbert E. Huppert, J. Stewart Turner
openaire   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Flow Convergence Caused by a Salinity Minimum in a Tidal Channel

San Francisco Estuary and Watershed Science, 2006
Residence times of dissolved substances and sedimentation rates in tidal channels are affected by residual (tidally averaged) circulation patterns. One influence on these circulation patterns is the longitudinal density gradient.
John C. Warner, David H. Schoellhamer, Jon R. Burau, S. Geoffrey Schladow   +3 more
doaj  

Distribution of intertidal macrobenthic assemblages in relation to environmental factors in the Tagus estuary, western Portugal

Scientia Marina, 2013
Fourteen intertidal sites from the eastern mid-region of the Tagus estuary were considered in order to study their macrobenthic assemblages in relation to environmental factors.
Anxo Conde, Júlio M. Novais, Jorge Domínguez   +2 more
doaj   +1 more source

Responses of Seagrass Amphibolis antarctica Roots to Nutrient Additions Along a Salinity Gradient in Shark Bay, Western Australia

Omni-Akuatika, 2021
Seagrass meadows in oligotrophic environments are particularly susceptible to nutrient enrichment, yet morphological and architectural seagrass root responses in these ecosystems are poorly understood.
Husen Rifai, Firman Zulpikar, Muhammad Safaat, Jeverson Renyaan, Laode Alifatri, Asep Rasyidin   +5 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source