Results 31 to 40 of about 30,327 (259)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
IEEE Access, 2021 Salinity gradient power (SGP) derived from sea and fresh water through reverse electrodialysis (RED) is an emerging discipline with huge potential for carbon-free energy harvesting.
Zhihong Yan +6 more
doaj +1 more source
PLoS ONE, 2020 The Bermuda Testbed Mooring (BTM) and Bay of Bengal Ocean Acidification (BOBOA) mooring measurements were used to identify changes in the partial pressure of CO2 at the sea surface (pCO2sea) and air-sea CO2 fluxes (FCO2) associated with passage of two ...
Haijun Ye +6 more
doaj +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Engineered ScienceThe use of asymmetric ion-selective membranes for harvesting salinity energy has attracted widespread attention. Among them, gradient polyelectrolyte hydrogels exhibit excellent power generation potential due to their abundant charged groups and ion ...
Caijian Wang +6 more
doaj +1 more source
Agronomy, 2022 Salinization is considered a threat to agricultural soil and decreases crop yield worldwide. Nitrification and denitrification are the core processes of soil N-cycle.
Daqing Huang, Xiang Li, Xuesong Luo
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The power of salinity gradients: An Australian example [PDF]
Renewable and Sustainable Energy Reviews, 2015 Abstract The development and exploitation of sustainable and environmentally friendly energy sources are required in order to resolve global energy shortages and to reduce the reliance of many countries on fossil fuel combustion. Salinity gradient energy has been considered a potential candidate for renewable energy due to the abundance of saline ...
Fernanda Helfer, Charles Lemckert
openaire +2 more sources