Results 51 to 60 of about 2,008,563 (295)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Energy Harvesting from Salinity Gradient
IOP Conference Series: Earth and Environmental Science, 2018 Abstract: Energy harvesting from salt water received attention started back in 1970s', but due to varying interests in the field and the growing potentials of other more promising sources, more work was required to fully establish it. This paper aims at identifying existing techniques of energy harvesting and the methodology involved determining an ...
B Muhthassim, X K Thian, K N Md Hasan
openaire +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
A Salinity Threshold Separating Fungal Communities in the Baltic Sea
Frontiers in Microbiology, 2019 Salinity is a significant factor for structuring microbial communities, but little is known for aquatic fungi, particularly in the pelagic zone of brackish ecosystems.
Keilor Rojas-Jimenez +8 more
doaj +1 more source
Omni-Akuatika, 2021 Seagrass meadows in oligotrophic environments are particularly susceptible to nutrient enrichment, yet morphological and architectural seagrass root responses in these ecosystems are poorly understood.
Husen Rifai +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
PLoS ONE, 2020 The Bermuda Testbed Mooring (BTM) and Bay of Bengal Ocean Acidification (BOBOA) mooring measurements were used to identify changes in the partial pressure of CO2 at the sea surface (pCO2sea) and air-sea CO2 fluxes (FCO2) associated with passage of two ...
Haijun Ye +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Flow Convergence Caused by a Salinity Minimum in a Tidal Channel
San Francisco Estuary and Watershed Science, 2006 Residence times of dissolved substances and sedimentation rates in tidal channels are affected by residual (tidally averaged) circulation patterns. One influence on these circulation patterns is the longitudinal density gradient.
John C. Warner +3 more
doaj