Results 61 to 70 of about 247,425 (305)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Attenuation of salinity-induced stress and improvement of brackish water aquaculture of Labeo rohita through dietary interventions of multi-species probiotics

Applied Water Science
The present investigation was targeted to determine the attenuating role of multi-species probiotics (MSP) of Bacillus subtilis (1.9 × 1010 CFU/g), Bacillus licheniformis (2 × 1010 CFU/g), and Clostridium butyricum (2.2 × 108 CFU/g), against salinity ...
Habiba Jamil, Abdul Ghaffar, Fozia Afzal, Hussain Ahmad, Ghulam Abbas, Dalia Fouad, Farid Shokry Ataya, Kun Li   +7 more
doaj   +1 more source

A pivotal role for starch in the reconfiguration of 14C-partitioning and allocation in Arabidopsis thaliana under short-term abiotic stress. [PDF]

, 2018
Plant carbon status is optimized for normal growth but is affected by abiotic stress. Here, we used 14C-labeling to provide the first holistic picture of carbon use changes during short-term osmotic, salinity, and cold stress in Arabidopsis thaliana ...
A Graf, A Harb, A Scialdone, A Skirycz, AM Smith, AM Smith, AR Fernie, AR Fernie, C Henry, C Polge, C Valerio, CM Figueroa, CR Lin, D Luquet, DR Geiger, DW Lawlor, E Baena-Gonzalez, E Keunen, F Kaplan, F Kaplan, F Rolland, H Ishihara, HJ Chen, I Hummel, II Hoermiller, JC Yang, JD Monroe, JM Cross, K Kolling, KE Koch, KJ Livak, LQ Chen, LQ Chen, M Durand, M Durand, M Izumi, M Jossier, M Nagao, M Stitt, M Stitt, M Thalmann, M Thalmann, M Thitisaksakul, M Thitisaksakul, M Zanella, ME Balibrea, MY Hu, N Avonce, N Ceusters, R Brouquisse, R Sicher, R Sulpice, R Yano, RF Baker, RS McKibbin, S Emanuelle, S Kempa, SM Cuellar-Ortiz, SM Pilkington, SM Yu, V Oury, W Pattanagul, WL Araujo, XC Wang, YG Yin, ZC Wang, ZF Gao   +66 more
core   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Chytridiomycosis of marine diatoms : the role of stress physiology and resistance in parasite-host recognition and accumulation of defense molecules [PDF]

, 2017
Little is known about the role of chemotaxis in the location and attachment of chytrid zoospores to potential diatom hosts. Hypothesizing that environmental stress parameters affect parasite-host recognition, four chytrid-diatom tandem cultures ...
Karsten, Ulf, Küpper, Frithjof C, Scholz, Bettina, Vyverman, Wim, Ólafsson, Halldór   +4 more
core   +7 more sources

Efecto del estrés producido por la mezcla de sales en la concentración de aldehído malónico, proteínas y enzimas antioxidantes de Leymus chinensis de tres colores foliares diferentes [PDF]

, 2017
The mixed salt stress is common in nature. Salt stressalways affects plant growth. Different plant species have different adaptive capacity to salty soil. Leymus chinensis is an herbaceous plant with different leaf colors.
Busso, Carlos Alberto, Han, X. G., Wang, Z. W., Yang, Y. F., Yang, Y. G., Zhang, Z., Zhou, C.   +6 more
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Grain Yield, Biomass Accumulation, and Leaf Photosynthetic Characteristics of Rice under Combined Salinity-Drought Stress

Rice Science
Simultaneous stresses of salinity and drought often coincide during rice-growing seasons in saline lands, primarily due to insufficient water resources and inadequate irrigation facilities.
Wei Huanhe, Geng Xiaoyu, Zhang Xiang, Zhu Wang, Zhang Xubin, Chen Yinglong, Huo Zhongyang, Zhou Guisheng, Meng Tianyao, Dai Qigen   +9 more
doaj   +1 more source

The effect of humic acid on growth, yield, and some physiological parameters of wheat under salinity stress [PDF]

فیزیولوژی محیطی گیاهی, 2020
Salinity is a major environmental stress, reducing growth and yield of a wide variety of crops all over the world. The present study assessed effects of humic acid and salinity stress on the growth and some physiological responses of wheat in a pot ...
Reza Sharifi Asl, Mahnaz Jasemi Manesh, Mohammad Mirzaie Haydari   +2 more
doaj  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source