Results 91 to 100 of about 169,118 (334)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
The Arabidopsis transcription factor MYB112 promotes anthocyanin formation during salinity and under high light stress [PDF]
, 2015 Magda E. Lotkowska +5 more
openalex +1 more source
Reducing poverty through integrated management of groundwater and surface water [PDF]
Groundwater management / Irrigation management / Domestic water / Poverty / Asia / India ...
International Water Management Institute (IWMI) / Global Water Partnership (GWP) Advisory Center
core
Microfluidic electro‐viscoelastic manipulation of extracellular vesicles
FEBS Open Bio, EarlyView.The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh +7 more
wiley +1 more source
Implications of land and water degradation on food security [PDF]
Land degradation / Erosion / Water pollution / Sedimentation / Groundwater depletion / Salt water intrusion / Soil salinity / Urbanization ...
Jinendradasa, Sithara
core
FEBS Open Bio, EarlyView.Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel +9 more
wiley +1 more source
An overview on the state of art on IAH coastal aquifer dynamics and coastal zone website
Acque Sotterranee, 2019 The website of the IAH Coastal Aquifer Dynamics and Coastal Zone Management (CAD-CZM) Network, linkable at the web address www.iah-cad-czm.net, aims at improving the knowledge about coastal aquifer for supporting worldwide the assessment, development and
Giuseppe Sappa, Flavia Ferranti
doaj +1 more source
Potential of temperature- and salinity-driven shifts in diatom compatible solute concentrations to impact biogeochemical cycling within sea ice [PDF]
, 2020 Hannah M. Dawson +5 more
openalex +1 more source