Results 51 to 60 of about 3,416 (214)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Salinization Decreases Soil Phosphorus Availability and Plant Productivity in Terrestrial Ecosystems

Earth's Future
Soil phosphorus (P) availability is crucial for plant productivity, and salinization is generally expected to reduce plant productivity in global terrestrial ecosystems. However, the response of soil P availability to salinization remains unclear, making
Meimei Li, Matthew D. Petrie, Xiaotao Lü, Jiajia Wang, Xibin Sun, Nan Hu, Hao Chen   +6 more
doaj   +1 more source

Provision of Desalinated Irrigation Water by the Desalination of Groundwater within a Saline Aquifer

Hydrology, 2016
Irrigated land accounts for 70% of global water usage and 30% of global agricultural production. Forty percent of this water is derived from groundwater.
David D. J. Antia
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Evolution Patterns and Dominant Factors of Soil Salinization in the Yellow River Delta Based on Long-Time-Series and Similar Phenological-Fusion Images

Remote Sensing
Previous studies were mostly conducted based on sparse time series and different phenological images, which often ignored the dramatic changes in salinization evolution throughout the year.
Bing Guo, Mei Xu, Rui Zhang
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Estimating the groundwater table threshold for mitigating soil salinization in the Songnen Plain of China

Journal of Hydrology: Regional Studies
Study region: The Songnen Plain is a key part of China’s largest plain, situated in northeastern China. Study focus: Soil salinization has become one of the largest ecological issues in the Songnen Plain, and regulating groundwater levels is a crucial ...
Yiding Ding, Haishen Lü, Ligang Xu, Robert Horton, Mingliang Jiang, Yonghua Zhu, Junxiang Cheng, Hongxiang Fan, Jianbin Su   +8 more
doaj   +1 more source

Seasonal Salinization Decreases Spatial Heterogeneity of Sulfate Reducing Activity

Soil Systems, 2019
Evidence of sulfate input and reduction in coastal freshwater wetlands is often visible in the black iron monosulfide (FeS) complexes that form in iron rich reducing sediments.
Valerie A. Schoepfer, Amy J. Burgin, Terry D. Loecke, Ashley M. Helton   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source