Results 121 to 130 of about 7,383 (256)

Glucose starvation-mediated inhibition of salinomycin induced autophagy amplifies cancer cell specific cell death

, 2015
Salinomycin has been used as treatment for malignant tumors in a small number of humans, causing far less side effects than standard chemotherapy. Several studies show that Salinomycin targets cancer-initiating cells (cancer stem cells, or CSC) resistant
Hallbeck, Anna-Lotta,, Los, Marek Jan,, Roberg, Karin,, Marek J. Łos, Jaganmohan R. Jangamreddy, Anna-Lotta Hallbeck, Kourosh Lotfi, Jain, Mayur V.,, Mayur V. Jain, Karin Roberg, Lotfi, Kourosh,, Jangamreddy, Jaganmohan Reddy,   +11 more
core   +1 more source

Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity : Differences between primary and cancer cells

, 2013
The molecular mechanism of Salinomycin's toxicity is not fully understood. Various studies reported that Ca2 +, cytochrome c, and caspase activation play a role in Salinomycin-induced cytotoxicity.
Ghavami, Saeid, Kratz, Gunnar, Łos, Marek J., Rao, Rama K.,, Jangamreddy, Jaganmohan,, Wiechec, Emilia,, Cieślar-Pobuda, Artur,, Łos, Marek,, Cieślar-Pobuda, Artur, Łos, Marek, Ghavami, Saeid,, Rao, Rama K., Grabarek, Jerzy,, Grabarek, Jerzy, Fredriksson, Bengt-Arne, Jangamreddy, Jaganmohan, Kratz, Gunnar,, Panigrahi, Soumya, Panigrahi, Soumya,, Fredriksson, Bengt-Arne,, Wiechec, Emilia, Jangamreddy, Jaganmohan Reddy, Rao Pariti, Rama Krishna   +22 more
core   +1 more source

Dose-dependent adverse effects of salinomycin on male reproductive organs and fertility in mice.

PLoS ONE, 2013
Salinomycin is used as an antibiotic in animal husbandry. Its implication in cancer therapy has recently been proposed. Present study evaluated the toxic effects of Salinomycin on male reproductive system of mice.
Olajumoke Omolara Ojo, Smrati Bhadauria, Srikanta Kumar Rath   +2 more
doaj   +1 more source

Differential effects of drugs targeting cancer stem cell (CSC) and non-CSC populations on lung primary tumors and metastasis.

PLoS ONE, 2013
Cancer stem cells (CSCs) are thought to be responsible for tumor initiation and recurrence after chemotherapy. Targeting CSCs and non-CSCs with specific compounds may be an effective approach to reduce lung cancer growth and metastasis.
Leyre Larzabal, Nefertiti El-Nikhely, Miriam Redrado, Werner Seeger, Rajkumar Savai, Alfonso Calvo   +5 more
doaj   +1 more source

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source

Semi-synthetic salinomycin analogs exert cytotoxic activity against human colorectal cancer stem cells

, 2018
Salinomycin, a polyether antibiotic, is a well-known inhibitor of human cancer stem cells. Chemical modification of the allylic C20 hydroxyl of salinomycin has enabled access to synthetic analogs that display increased cytotoxic activity compared to the ...
Ulrich, Alexis, Claudia Volz, Martin Schneider, Daniel Strand, Thomas Schmidt, Schneider, Martin, Björn Borgström, Oredsson, Stina, Klose, Johannes, Johannes Klose, Sarah Kattner, Volz, Claudia, Kattner, Sarah, Borgström, Björn, Stina Oredsson, Schmidt, Thomas, Strand, Daniel, Alexis Ulrich   +17 more
core   +1 more source

Salinomycin induces apoptosis in colorectal cancer TICs.

, 2019
TIC cultures from patients 1–4 were cultured in the absence or presence of increasing concentrations of salinomycin, 5-fluorouracil, and oxaliplatin (1, 2, 5, and 10 μM) for 24 and 48 hours.
Arsalie Preißendörfer Charrier (6335654), Alexis Ulrich (565903), Praveen Radhakrishnan (3536891), Stefan Trefz (6335648), Hanno Glimm (200902), Tobias Wagner (189184), Martin Schneider (101577), Thomas Schmidt (168952), Claudia Volz (3580931), Claudia Ball (6335660), Johannes Klose (562050), Luca Steffen (6335651), Sebastian M. Dieter (6335657)   +12 more
core   +1 more source

Cloning and Characterization of the Polyether Salinomycin Biosynthesis Gene Cluster of Streptomyces albus XM211

, 2012
Salinomycin is widely used in animal husbandry as a food additive due to its antibacterial and anticoccidial activities. However, its biosynthesis had only been studied by feeding experiments with isotope-labeled precursors.
Hougen Wang, Qianjin Kang, Linquan Bai, Chunyan Jiang, Jing Liu   +4 more
core   +1 more source

Combination of salinomycin and silver nanoparticles enhances apoptosis and autophagy in human ovarian cancer cells: an effective anticancer therapy

, 2016
Xi-Feng Zhang,1 Sangiliyandi Gurunathan2 1College of Biological and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan, People’s Republic of China; 2Department of Stem Cell and Regenerative Biology, Konkuk University, Seoul, South ...
Gurunathan S, Zhang XF
core  

Salinomycin encapsulated nanoparticles as a targeting vehicle for glioblastoma cells

, 2015
Salinomycin has been introduced as a novel alternative to traditional anti-cancer drugs. The aim of this study was to test a strategy designed to deliver salinomycin to glioblastoma cells in vitro.
Aydin, R. Seda Tigli, Kaynak, Gokce, Menemşe Gümüşderelioğlu, R. Seda Tığlı Aydın, TIĞLI AYDIN, RAHİME SEDA, GÜMÜŞDERELİOĞLU, MENEMŞE, Gökçe Kaynak   +6 more
core   +1 more source