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The Endocrinologist, 2000
One of the hallmarks of the hypothalamic-pituitary-adrenal (HPA) axis is a distinctive circadian rhythm with a peak in cortisol at 8 a.m. and a nadir around midnight. Because patients with endogenous hypercortisolism have an increase in the nadir in the circadian rhythm of cortisol, the ability to ...
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One of the hallmarks of the hypothalamic-pituitary-adrenal (HPA) axis is a distinctive circadian rhythm with a peak in cortisol at 8 a.m. and a nadir around midnight. Because patients with endogenous hypercortisolism have an increase in the nadir in the circadian rhythm of cortisol, the ability to ...
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Stress and salivary cortisol during pregnancy
Psychoneuroendocrinology, 2005The purpose of this study was to determine whether exposure to stressful life events was associated with changes in levels of circulating cortisol during pregnancy in a population of 603 pregnant women. The participating pregnant women filled out a questionnaire and collected a morning and evening sample of saliva in early pregnancy (median 14th ...
Obel, Carsten +5 more
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Salivary Cortisol in Psychobiological Research: An Overview
Neuropsychobiology, 2008The measurement of cortisol in saliva provides the basic scientist as well as the clinician with a reliable tool for investigations of hypothalamus-pituitary-adrenal axis activity. Since saliva samples can be obtained stress-free and independent from medically trained personnel this method may be well suited for use in psychobiological studies.
C, Kirschbaum, D H, Hellhammer
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Salivary Cortisol Testing in Children
Issues in Comprehensive Pediatric Nursing, 1997Biological markers can identify links between human biology and human behavior. Cortisol, a marker of hypothalamic-pituitary-adrenocortical axis function, is a useful measure in research. Newer technology involving the measurement of cortisol in saliva is being utilized in research studies.
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Upright posture influences salivary cortisol
Psychoneuroendocrinology, 2000This study was designed to investigate the influence of posture on salivary cortisol concentrations in healthy volunteers. In a balanced cross-over design 24 subjects were exposed at 1 week intervals to different body positions (sitting [S], lying [L] upright [U]) for 20 min in each condition.
J, Hennig +5 more
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Optimism, positive affectivity, and salivary cortisol
British Journal of Health Psychology, 2005Objectives. Research on stress and salivary cortisol has focused almost exclusively on the effects of negative psychological conditions or emotional states. Little attention has been drawn to the impact associated with positive psychological conditions, which have been shown recently to have significant ...
Chan, CLW +9 more
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Salivary cortisol as a biomarker in stress research
Psychoneuroendocrinology, 2009Salivary cortisol is frequently used as a biomarker of psychological stress. However, psychobiological mechanisms, which trigger the hypothalamus-pituitary-adrenal axis (HPAA) can only indirectly be assessed by salivary cortisol measures. The different instances that control HPAA reactivity (hippocampus, hypothalamus, pituitary, adrenals) and their ...
Dirk H, Hellhammer +2 more
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Salivary Cortisol Predicts Cardiovascular Mortality
Current Hypertension Reports, 2011Methods: The Whitehall II study was a prospective cohort study conducted among civil servants in the United Kingdom, with the participation of 6,941 individuals. The mean age of participants was 61 years and the mean duration of follow-up was 6.1 years. Sequential salivary samples taken from waking to bedtime were analyzed.
Reshma, Pahuja, Theodore A, Kotchen
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Long‐term stability of salivary cortisol
Scandinavian Journal of Clinical and Laboratory Investigation, 2005The measurement of salivary cortisol provides a simple, non-invasive, and stress-free measure frequently used in studies of the hypothalamic-pituitary-adrenal axis activity. In research projects, samples are often required to be stored for longer periods of time either because of the protocol of the project or because of lack of funding for analysis ...
Garde, A H, Hansen, Åse Marie
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Polarisation fluoroimmunoassay of serum and salivary cortisol
Journal of Steroid Biochemistry, 1983Polarisation fluoroimmunoassays for serum and salivary cortisol were developed using the steroid labelled at the 3-position with fluorescein and antiserum raised in sheep. To avoid interfering factors present in the biological fluids, cortisol was extracted with dichloromethane prior to assay, which was then accomplished without the need for any ...
A A, Al-Ansari, D S, Smith, J, Landon
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