Results 71 to 80 of about 721,774 (392)

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Sphingosine-1-phosphate alleviates colitis by regulating macrophage polarization and PI3k-Akt signaling

Frontiers in Immunology
IntroductionInflammatory bowel disease (IBD) is a complex disease that is characterized by tight junction loss and dysregulation of immune homeostasis.
Liang Hu, Zi Yang, Zi Yang, Ying Zhang, Conglin Du, Yang Yang, Yang Yang, Zhichao Chang, Xiangchun Li, Zhaochen Shan   +9 more
doaj   +1 more source

Morphological pattern of salivary gland tumours [PDF]

, 2001
Objective: To delineate the spectrum of salivary gland tumors in our setup. Setting: The Aga Khan University Medical Centre, Karachi. Method: Tumors were analysed considering histological type, age and sex of the patients and anatomic location.
Gill, M. S., Hasan, S. H., Hussainy, A. S., Kayani, Naila, Muzaffar, S., Pervez, Shahid, Soomro, I. N.   +6 more
core   +1 more source

Endosomal Rab GTPases regulate secretory granule maturation in Drosophila larval salivary glands [PDF]

, 2021
J. Cheng-I, Julie A. Brill
openalex   +1 more source

DENTA: A Dual Enzymatic Nanoagent for Self‐Activating Tooth Whitening and Biofilm Disruption

Advanced Functional Materials, EarlyView.
The nanoapatite with dual enzymes (DENTA) accumulates in dentinal tubules, reducing hypersensitivity caused by dental nerve exposure and facilitating continuous ROS generation through salivary glucose for effective, long‐term whitening. The dentin structures remain non‐destructive due to the low concentration of ROS, demonstrating excellent cell ...
Junseok Kim, Dai‐Hwan Kim, Priyannth R. Sundharbaabu, Chae Yeon Lee, Jina Bae, Jiyu Hyun, Young‐Ju Jang, Haeni Kim, Min‐Ho Hong, Juewen Liu, Tobias Fey, Suk Ho Bhang, Jun Hyuk Heo, Jung Heon Lee   +13 more
wiley   +1 more source

pH‐Tunable Material Properties of Glycine‐Rich Condensates from Tick Bioadhesive

Advanced Functional Materials, EarlyView.
This work studies the influence of pH on the phase separation behavior of a disordered glycine‐rich protein found in tick bioadhesive. The results show profound impact on the propensity of coacervation, condensate microstructure and viscosity, amphiphilicity of the peptides, and effective encapsulation of therapeutic molecules.
Manali Nandy, Udit Ghosh, Ketan A. Ganar, Hans Ippel, Ingrid Dijkgraaf, Siddharth Deshpande   +5 more
wiley   +1 more source

Salivary Gland Sonography in Patients with Primary Fibromyalgia—A Pilot Study

Life
Primary Sjogren’s syndrome (pSS) is often concomitant with fibromyalgia (FM). Salivary gland sonography aids in the diagnosis of pSS. We aimed to discover, in primary FM patients, the presence of pSS in undiagnosed patients through salivary gland ...
Ching-Tsai Lin, Der-Yuan Chen, Yi-Hsing Chen, Chien-Chen Lai, Kuo-Tung Tang   +4 more
doaj   +1 more source

Botulinum toxin therapy: functional silencing of salivary disorders. [PDF]

, 2017
Botulinum toxin (BTX) is a neurotoxic protein produced by Clostridium botulinum, an anaerobic bacterium. BTX therapy is a safe and effective treatment when used for functional silencing of the salivary glands in disorders such as sialoceles and salivary ...
Lovato, A, Marchese Ragona, R., Marioni, Gino, Ottaviano, Giancarlo, Restivo, Da   +4 more
core  

Proteomic analysis of Glossina pallidipes salivary gland hypertrophy virus virions for immune intervention in tsetse fly colonies [PDF]

, 2010
Many species of tsetse flies (Diptera: Glossinidae) can be infected by a virus that causes salivary gland hypertrophy (SGH). The viruses isolated from Glossina pallidipes (GpSGHV) and Musca somestica (MdSGHV) have recently been sequenced.
Abd-Alla, A.M.M., Bergoin, M., Boeren, S., Ince, I.A., Kariithi, H.M., Oers, M.M., van, Vervoort, J.J.M., Vlak, J.M.   +7 more
core   +2 more sources

Biological Therapy in Primary Sjögren's Syndrome: Effect on Salivary Gland Function and Inflammation [PDF]

, 2021
Farzana Chowdhury, Anwar R. Tappuni, Stefano Bombardieri   +2 more
openalex   +1 more source