Results 91 to 100 of about 6,750,036 (340)

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins [PDF]

, 2014
An expanded GGGGCC repeat in C9orf72 is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. A fundamental question is whether toxicity is driven by the repeat RNA itself and/or by dipeptide repeat proteins ...
Cabecinha, M, Clayton, EL, Cleverley, K, Devoy, A, Dols, J, Fisher, EMC, Fratta, P, Grönke, S, Hendrich, O, Isaacs, AM, Mizielinska, S, Moens, T, Niccoli, T, Nicoll, AJ, Norona, FE, Partridge, L, Pickering-Brown, S, Pietrzyk, J, Ridler, CE, Woollacott, IOC   +19 more
core   +1 more source

Salivary Antioxidant Barrier, Redox Status, and Oxidative Damage to Proteins and Lipids in Healthy Children, Adults, and the Elderly

Oxidative Medicine and Cellular Longevity, 2019
Despite the proven role of oxidative stress in numerous systemic diseases and in the process of aging, little is still known about the salivary redox balance of healthy children, adults, and the elderly.
M. Maciejczyk, A. Zalewska, J. Ładny
semanticscholar   +1 more source

Epidermal Patch Technologies for Integrated Healthcare and Infection Management

Advanced Healthcare Materials, EarlyView.
Epidermal patches have evolved from simple wound coverings into multifunctional, skin‐conformable platforms integrating drug delivery, biosensing, and therapeutic functionalities. This review highlights their material innovations, fabrication strategies, and intelligent designs, including hydrogels, microneedles, and flexible electronics, while ...
Yuqi Wang, Atakan Tevlek, Pawel L. Urban, Boaz Mizrahi, Onome Ejeromedoghene, Roshan Deen, Yuanjing Lin, Jagan Mohan Dodda   +7 more
wiley   +1 more source

The structures of two salivary proteins from the West Nile vector Culex quinquefasciatus reveal a beta-trefoil fold with putative sugar binding properties

Current Research in Structural Biology, 2021
Female mosquitoes require blood meals for egg development. The saliva of blood feeding arthropods contains biochemically active molecules, whose anti-hemostatic and anti-inflammatory properties facilitate blood feeding on vertebrate hosts.
Olivia Kern, Paola Carolina Valenzuela Leon, Apostolos G. Gittis, Brian Bonilla, Phillip Cruz, Andrezza Campos Chagas, Sundar Ganesan, Jose M.C. Ribeiro, David N. Garboczi, Ines Martin-Martin, Eric Calvo   +10 more
doaj   +1 more source

Proline-Rich Salivary Proteins Have Extended Conformations [PDF]

Biophysical Journal, 2010
Three basic proline-rich salivary proteins have been produced through the recombinant route. IB5 is a small basic proline-rich protein that is involved in the binding of plant tannins in the oral cavity. II-1 is a larger protein with a closely related backbone; it is glycosylated, and it is also able to bind plant tannins.
Boze, Helene, Marlin, Therese, Durand Dominique, Dominique, Perez, Javier, Vernhet, Aude, Canon, Francis, Manchado-Sarni, Pascale, Cheynier, Veronique, Cabane, Bernard   +8 more
openaire   +3 more sources

Polycomb group protein complexes exchange rapidly in living Drosophila [PDF]

, 2005
Fluorescence recovery after photobleaching (FRAP) microscopy was used to determine the kinetic properties of Polycomb group (PcG) proteins in whole living Drosophila organisms (embryos) and tissues (wing imaginal discs and salivary glands). PcG genes are
Arndt-Jovin, D., Ficz, G., Heintzmann, R.   +2 more
core  

TRPC1 regulates calcium-activated chloride channels in salivary gland cells [PDF]

, 2015
Calcium-activated chloride channel (CaCC) plays an important role in modulating epithelial secretion. It has been suggested that in salivary tissues, sustained fluid secretion is dependent on Ca2+ influx that activates ion channels such as CaCC to ...
Birnbaumer, Lutz, Singh, Brij B., Sun, Yuyang   +2 more
core   +1 more source

Electrically Readable Lateral Flow Assay Using Organic Transistors for Diagnostic Applications

Advanced Materials, EarlyView.
Electrolyte‐gated organic field‐effect transistors (EGOFETs) are integrated with lateral flow (LF) paper fluidics to create a reusable, portable, and low‐cost point‐of‐care (PoC) diagnostic test. The devices are validated for Human Immunoglobulin G detection, achieving high sensitivity (0.1 fm), selectivity, and reproducibility with rapid results in 20–
María Jesús Ortiz‐Aguayo, Carme Martínez‐Domingo, Diego Gutiérrez, Dean Kos, Marta Mas‐Torrent   +4 more
wiley   +1 more source

Proteomic informed by transcriptomic for salivary glands components of the camel tick Hyalomma dromedarii

BMC Genomics, 2019
Background The hard tick Hyalomma dromedarii is one of the most injurious ectoparasites affecting camels and apparently best adapted to deserts. As long-term blood feeders, ticks are threatened by host defense system compounds that can cause them to be ...
Chaima Bensaoud, Hajer Aounallah, Juliana Mozer Sciani, Fernanda Faria, Ana Marisa Chudzinski-Tavassi, Ali Bouattour, Youmna M’ghirbi   +6 more
doaj   +1 more source

Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches

BMC Genomics, 2020
Background Salivary cell secretion (SCS) plays a critical role in blood feeding by medicinal leeches, making them of use for certain medical purposes even today.
Vladislav V. Babenko, Oleg V. Podgorny, Valentin A. Manuvera, Artem S. Kasianov, Alexander I. Manolov, Ekaterina N. Grafskaia, Dmitriy A. Shirokov, Alexey S. Kurdyumov, Dmitriy V. Vinogradov, Anastasia S. Nikitina, Sergey I. Kovalchuk, Nickolay A. Anikanov, Ivan O. Butenko, Olga V. Pobeguts, Daria S. Matyushkina, Daria V. Rakitina, Elena S. Kostryukova, Victor G. Zgoda, Isolda P. Baskova, Vladimir M. Trukhan, Mikhail S. Gelfand, Vadim M. Govorun, Helgi B. Schiöth, Vassili N. Lazarev   +23 more
doaj   +1 more source