Results 121 to 130 of about 757,640 (413)

Facilitating crRNA Design by Integrating DNA Interaction Features of CRISPR‐Cas12a System

Advanced Science, EarlyView.
This study introduces a novel approach combining molecular dynamics simulations and neural network modeling to predict the Cas12a trans‐cleavage activity. By integrating sequence and molecular interaction features, prediction accuracy is enhanced, and identify key features affecting Cas12a trans‐cleavage activity.
Zhihao Yao, Wanglu Li, Kaiyu He, Hongmei Wang, Yan Xu, Qun Wu, Liu Wang, Yao Nie   +7 more
wiley   +1 more source

An Extreme Value Theory approach for the early detection of time clusters with application to the surveillance of Salmonella [PDF]

arXiv, 2010
We propose a method to generate a warning system for the early detection of time clusters applied to public health surveillance data. This new method relies on the evaluation of a return period associated to any new count of a particular infection reported to a surveillance system. The method is applied to Salmonella surveillance in France and compared
arxiv  

Salmonella infection - prevention and treatment by antibiotics and probiotic yeasts: a review.

Microbiology, 2018
Global Salmonella infection, especially in developing countries, is a health and economic burden. The use of antibiotic drugs in treating the infection is proving less effective due to the alarming rise of antibiotic-resistant strains of Salmonella, the ...
Abraham Majak Gut, T. Vasiljevic, T. Yeager, O. Donkor   +3 more
semanticscholar   +1 more source

A Smart Single‐Loop‐Mediated Isothermal Amplification Facilitates Flexible SNP Probe Design for On‐Site Rapid Differentiation of SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
The ssLAMP method amplifies the nucleic acid of pathogen and identifies SNP mutations. By combining the portable detection device with smartphone‐based analysis software, enables rapid, on‐site SNP detection and genotyping of SARS‐Cov‐2 Omicron variants, providing a cost‐effective and field‐deployable solution for precise pathogen identification in ...
Qijie Lin, Hongchao Gou, Xiaoyun Qu, Kaiyuan Jia, Yuhui Deng, Dan Li, Qianyi Cai, Yucen Liang, Xiaozhen Xu, Yanbin Li, Jianhan Lin, Letian Li, Yuhang Jiang, Shouwen Du, Lingcong Deng, Bailing Yan, Ruidong Liu, Chang Li, Jianmin Zhang, Ming Liao   +19 more
wiley   +1 more source

Detecting and monitoring foodborne illness outbreaks: Twitter communications and the 2015 U.S. Salmonella outbreak linked to imported cucumbers [PDF]

arXiv, 2017
This research uses Twitter, as a social media device, to track communications related to the 2015 U.S. foodborne illness outbreak linked to Salmonella in imported cucumbers from Mexico. The relevant Twitter data are analyzed in light of the timeline of the official announcements made by the Centers for Disease Control and Prevention (CDC).
arxiv  

Host resistance factor SLC11A1 restricts Salmonella growth through magnesium deprivation

Science, 2019
Magnesium for Salmonella growth In mammals, macrophages are a first line of defense against pathogenic bacteria like Salmonella. These immune cells possess a metal-ion transporter called SLC11A1 or NRAMP1, which is known to be involved in infection ...
Olivier Cunrath, D. Bumann
semanticscholar   +1 more source

Elicitation of expert knowledge on controlling Salmonella in the pork chain [PDF]

, 2002
Salmonella is one of the most important risks for food safety, and pork is one of the sources of human salmonellosis. A chain approach is essential to reduce Salmonella in pork products.
Gaag, M., v.d., Huirne, R.B.M.
core   +2 more sources

A Dual‐Targeting T6SS DNase Drives Bacterial Antagonism and Eukaryotic Apoptosis via the cGAS‐STING‐TNF Axis

Advanced Science, EarlyView.
The bacterial Type VI secretion system (T6SS) emerges as a sophisticated virulence mechanism, leveraging the dual‐function effector TkeA from Yersinia pseudotuberculosis. TkeA concurrently damages rival bacteria and host cell DNA, triggering the host's cGAS‐STING‐TNF pathway and inducing apoptosis.
Li Song, Lei Xu, Pengfei Zhang, Shuying Li, Yichen Qu, Yixin Zhao, Zhenkun Shi, Ruiqi Ma, Yongdong Li, Yi Chen, Yao Wang, Zhengfan Jiang, Gehong Wei, Xihui Shen   +13 more
wiley   +1 more source

Examining marginal sequence similarities between bacterial type III secretion system and Trypanosoma cruzi surface proteins: Horizontal gene transfer or convergent evolution? [PDF]

arXiv, 2012
The cell invasion mechanism of Trypanosoma cruzi has similarities with some intracellular bacterial taxa especially regarding calcium mobilization. This mechanism is not observed in other trypanosomatids, suggesting that the molecules involved in this type of cell invasion were a product of (1) acquired by horizontal gene transfer; (2) secondary loss ...
arxiv  

Non-typhoidal Salmonella in the Pig Production Chain: A Comprehensive Analysis of Its Impact on Human Health

Pathogens, 2019
Salmonellosis remains one of the most frequent foodborne zoonosis, constituting a worldwide major public health concern. The most frequent sources of human infections are food products of animal origin, being pork meat one of the most relevant. Currently,
Joana Campos, J. Mourão, L. Peixe, P. Antunes   +3 more
semanticscholar   +1 more source