Results 61 to 70 of about 420,558 (308)

Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron

Angewandte Chemie, EarlyView.
Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej, Arturo Rodríguez‐Banqueri, Danuta Mizgalska, Borys Szmigielski, Zuzanna Nowakowska, Małgorzata Benedyk‐Machaczka, Monika Bzowska, Katarzyna Mikruta, Juan Sebastián Ramírez‐Larrota, Chinanu Agunanne, Olivier Julien, Anthony J. O'Donoghue, Carsten Scavenius, Mario López‐Martín, Enrique Marcos, Łukasz Koziej, Sebastian Glatt, Pablo Guerra, Ulrich Eckhard, Jan Potempa, F. Xavier Gomis‐Rüth   +20 more
wiley   +2 more sources

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Salmonella transiently reside in luminal neutrophils in the inflamed gut. [PDF]

, 2012
Enteric pathogens need to grow efficiently in the gut lumen in order to cause disease and ensure transmission. The interior of the gut forms a complex environment comprising the mucosal surface area and the inner gut lumen with epithelial cell debris and
Mathias Heikenwalder (79126), Patrick Kaiser, Schubert Sören, Stecher, Bärbel, Wieser, Andreas, Kaiser, Patrick, Jette Lengefeld (172749), Schubert, Sören, Stecher, B., Andreas Wieser, Sören Schubert, Loetscher, Yvonne, Stecher Bärbel, Patrick Kaiser (172750), Wolf-Dietrich Hardt, Heikenwalder, Mathias, Lengefeld, J., Bärbel Stecher (78807), Jette Lengefeld, Schubert, S., Andreas Wieser (172747), Wieser Andreas, Loetscher, Y., Loetscher Yvonne, Wolf-Dietrich Hardt (46235), Lengefeld Jette, Heikenwälder, M., Yvonne Loetscher, Kaiser Patrick, Hardt Wolf-Dietrich, Wieser, A., Kaiser, P., Sören Schubert (172752), Bärbel Stecher, Heikenwalder Mathias, Hardt, W.D., Mathias Heikenwalder, Lengefeld, Jette, Hardt, Wolf-Dietrich; id_orcid, Yvonne Loetscher (172745), Hardt, Wolf-Dietrich   +40 more
core   +2 more sources

Insights into recurring multi-country outbreaks of Salmonella Strathcona associated with tomatoes, Europe, 2011 to 2024

Eurosurveillance
Notifications of Salmonella Strathcona infections increased in Europe in 2023 prompting a multi-country outbreak investigation. We aimed to describe the epidemiology of S.
Michael Pietsch
doaj   +1 more source

CHARACTERISTICS OF ACUTE INTESTINAL INFECTIONS IN CHILDREN HOSPITALIZED IN THE CLINIC IN MOSCOW

Детские инфекции (Москва), 2017
The article presents the results of the study of the etiological structure and clinical features of acute intestinal infections of viral, bacterial and mixed etiology in children hospitalized in a specialized department of Children's Clinical Hospital №9
O. B. Kovalev, A. A. Novokshonov, A. L. Rossina, S. B. Chuelov, O. V. Molochkova, A. A. Korsunsky, O. A. Kashchenko, E. V. Galeeva, N. I. Krylatova, E. Y. Pylaeva, V. E. Karaulova, S. A. Tesova, G. Y. Zhuravlev   +12 more
doaj   +1 more source

Salmonella osteomyelitis.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1974
An unusual case of disseminated Salmonella dublin infection in an infant is reported. The dominant localisation in metacarpals and metatarsals is regarded as an uncommon complication.S. Afr. Med. J., 48, 591 (1974)
Mackenjee, M.K.R., Coovadia, H.M., Naidoo, L.S.   +2 more
openaire   +3 more sources

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source

Comparative evaluation of planktonic and biofilm modes of growth in Salmonella Typhimurium [PDF]

, 2011
In this research, comparative studies of planktonic and biofilm modes of growth in Salmonella enterica serovar Typhimurium were undertaken. Chemical disinfectant studies were performed for both planktonic and biofilm Salmonella and biofilms at different ...
Wong, Hui San
core  

Chemoenzymatic Radiosynthesis of a Gluconate Transporter‐Targeted In Vivo Bacterial Sensor From Clinical [18F]FDG

Angewandte Chemie, EarlyView.
An efficient radiosynthesis of fluorine‐18 labeled gluconic acid ([18F]FGA) was developed using two readily available materials, 2‐deoxy‐2‐[18F]fluoro‐D‐glucose ([18F]FDG) and glucose oxidase. [18F]FGA is highly specific for bacterial gluconate metabolism mediated by gluconate permease (GntP) and gluconate kinase (GntK), with rapid clearance, low off ...
Sang Hee Lee, Jung Min Kim, Joseph Blecha, Robert R. Flavell, Michael A. Ohliger, Joanne Engel, Youngho Seo, David M. Wilson   +7 more
wiley   +2 more sources

Genomic insights of Salmonella isolated from dry fermented sausage production chains in Spain and France

Scientific Reports
The presence of Salmonella in dry fermented sausages is source of recalls and outbreaks. The genomic diversity of 173 Salmonella isolates from the dry fermented sausage production chains (pig carcasses, pork, and sausages) from France and Spain were ...
Núria Ferrer-Bustins, Claire Yvon, Belén Martín, Vincent Leclerc, Jean-Charles Leblanc, Laura Corominas, Sara Sabaté, Eva Tolosa-Muñoz, Carme Chacón-Villanueva, Sara Bover-Cid, Sabrina Cadel-Six, Anna Jofré   +11 more
doaj   +1 more source