Results 61 to 70 of about 925,108 (252)

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

A decline in the incidence of invasive non-typhoidal Salmonella infection in The Gambia temporally associated with a decline in malaria infection. [PDF]

, 2010
BACKGROUND: Malaria is a risk factor for invasive non-typhoidal Salmonella (NTS) infection in children. In the last 10 years, indices of malaria infection in The Gambia have fallen substantially.
Greenwood, Brian M, Tim O'Dempsey, Conway, David J., Bojang Kalifa A., Umberto D'Alessandro, Mackenzie Grant, D'Alessandro Umberto, Ikumapayi Usman N. A., Michael Walther, Kalifa A Bojang, Adegbola, Richard A., Saha, Debasish, Godwin Enwere, Philip C Hill, Serign J Ceesay, Conway David J., Walther, Michael, Usman N A Ikumapayi, Mackenzie, Grant, Greenwood Brian M., Debasish Saha, Tumani Corrah, Corrah, Tumani, Greenwood, Brian M., Hill, Philip C, Brian M Greenwood, Ikumapayi, Usman NA, Adegbola, Richard A, Corrah Tumani, Enwere, Godwin, Walther Michael, Grant Mackenzie, Conway, David J, Hill Philip C., O'Dempsey, Tim, David J Conway, Ceesay, Serign J, Bojang, Kalifa A, David C W Mabey, O'Dempsey Tim, Richard A Adegbola, Hill, Philip C., Judith Satoguina, O'Dempsey, Timothy, Saha Debasish, Bojang, Kalifa A., Mabey David C. W., D'Alessandro, Umberto, Enwere Godwin, Ceesay Serign J., Ikumapayi, Usman N.A., Adegbola Richard A., Mabey, David CW, Satoguina Judith, Mabey, David C.W., Ceesay, Serign J., Satoguina, Judith   +56 more
core   +2 more sources

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

Ileal Mucosal and Fecal Pancreatitis Associated Protein Levels Reflect Severity of Salmonella Inflection in Rats [PDF]

, 2009
Background Microbial infections induce ileal pancreatitis-associated protein/regenerating gene III (PAP/RegIII) mRNA expression. Despite increasing interest, little is known about the PAP/RegIII protein.
van der Meer, R., Bovee-Oudenhoven, I.M.J., Ampting, M.T.J., van, Schonewille, A., Kramer, E., Keijer, J., Meer, R., van der, van Ampting, M.T.J., Rodenburg, G.C.H., Vink, C.   +9 more
core   +1 more source

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

Advanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun, Teng Ma, Hao Jin, Zelong Li, Yi Cheng, Jingjin Li, Lai‐Yu Kwok, Zhihong Sun   +7 more
wiley   +1 more source

Critical Roles of O‐Acetylation Revealed by Synthetic Trisaccharide Antigens for a Broad‐Spectrum Anti‐Salmonella Vaccine

Advanced Science, EarlyView.
A synthetic glycoconjugate vaccine based on a diacetylated Salmonella trisaccharide elicits broadly protective antibodies against four major human pathogenic serovars. Mechanistic studies identify 2,3‐di‐O‐acetylation of rhamnose as a critical determinant of antigen recognition and breadth of protection, establishing a new strategy for broad‐spectrum ...
Xingling Pan, Soham Maity, Herbert Kavunja, Yuvarani Murali, Ting‐An Chen, Chang‐xin Huo, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +1 more source

Food Hygiene Practices of Vendors and Microbiological Quality of Ready to Eat Foods at Night Markets

AgriFood: Journal of Agricultural Products for Food, EarlyView.
This study investigates the relationship between food hygiene practices among night market vendors and the microbiological quality of ready to eat (RTE) foods sold at night markets. ABSTRACT Ready to eat (RTE) foods are popular options in night markets due to their convenience, affordability, and accessibility.
Yu Xin Soon, Kai Wen Koay, Seok Tyug Tan, Seok Shin Tan, Hariyono Hariyono, Chin Xuan Tan   +5 more
wiley   +1 more source

Slc11a1 limits intracellular growth of Salmonella enterica sv. Typhimurium by promoting macrophage immune effector functions and impairing bacterial iron acquisition

, 2009
The natural resistance-associated macrophage protein 1, Slc11a1, is a phagolysosomal transporter for protons and divalent ions including iron that confers host protection against diverse intracellular pathogens including Salmonella.
Fang, Ferric C., Nairz, Manfred, Weiss, Günter, Crouch, Marie-Laure V., Barton, Howard C., Fritsche, Gernot   +5 more
core   +1 more source

Salmonella enterica Serotype Choleraesuis Infection of the Knee and Femur in a Nonbacteremic Diabetic Patient

Case Reports in Infectious Diseases, 2013
Osteoarticular infections caused by Salmonella are rare. The rates of osteomyelitis and septic arthritis due to Salmonella are estimated to be less than 1% and 0.1%-0.2%, respectively (Kato et al., 2012).
Alexander M. Sy, Jagbir Sandhu, Theodore Lenox   +2 more
doaj   +1 more source