Results 101 to 110 of about 1,357,190 (346)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Accumulation conditions and exploration directions of natural gas in deep subsalt Sinian-Cambrian System in the eastern Sichuan Basin, SW China

Petroleum Exploration and Development, 2015
Based on comprehensive analysis of outcrops and drilling data, and interpretation of more than 6×104 km2 seismic data, this paper delineates the regional distribution of the gypsum-salt layers in Middle-Lower Cambrian in eastern Sichuan Basin, and ...
Zhidong GU, Jifeng YIN, Miao YUAN, Dongmei BO, Dongxing LIANG, Hang ZHANG, Li ZHANG   +6 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Biogeomorphically driven salt pan formation in Sarcocornia-dominated salt-marshes

Geomorphology, 2015
Abstract Salt-marshes are under increasing threat, particularly from sea-level rise and increased wave action associated with climate change. The development and stability of these valuable habitats largely depend on complex interactions between biotic and abiotic processes operating at different scales.
Escapa, Carlos Mauricio, Perillo, Gerardo Miguel E., Iribarne, Oscar Osvaldo   +2 more
openaire   +2 more sources

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Environmental protection of titanium alloys at high temperatures [PDF]

Various concepts were evaluated for protecting titanium alloys from oxygen contamination at 922 K (1200 F) and from hot-salt stress-corrosion at 755 K (900 F).
Seltzer, M. S., Wood, R. A., Wright, I. G.   +2 more
core   +1 more source

Study on micropore characteristics of aquifer in Huachi Formation of Binchang Mining Area

Meikuang Anquan
In view of the possible hydraulic connection between Huachi Formation and Luohe Formation aquifers in Binchang Mining area, uneven water richness in Huachi Formation aquifers, unclear porosity and permeability characteristics of salt-soluble mudstone in ...
Hongqiang ZHANG, Xiaolong LI
doaj   +1 more source

Enantioseparation of 3-Hydroxycarboxylic Acids via Diastereomeric Salt Formation by 2-Amino-1,2-diphenylethanol (ADPE) and Cinchonidine. [PDF]

Molecules, 2022
Chandrasekaran S, Tambo M, Yamazaki Y, Muramatsu T, Kanda Y, Hirose T, Kodama K.   +6 more
europepmc   +1 more source