Results 81 to 90 of about 1,357,190 (346)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Role of the Binder in Mitigating Salt Deposition in 100 cm2 Membrane Electrode Assembly CO2 Electrolyzers

Advanced Energy & Sustainability Research
The electrochemical reduction of carbon dioxide offers a promising approach to reduce CO2 emissions while producing valuable chemicals. To date, CO production in membrane electrode assembly (MEA) electrolyzers employing anion exchange membranes results ...
Laura Gatti, Sara Verhovez, Alessio Mezza, Marco Etzi, Stefano Stassi, Candido F. Pirri, Adriano Sacco   +6 more
doaj   +1 more source

Experimental study of the igbing properties of hydratic formation of sodium salt solutions [PDF]

E3S Web of Conferences
The paper presents some experimental studies of the process of the formation of methane gas hydrate in a cell containing in the initial state of methane and a solution of table salt.
Gimaltdinov Ilyas K., Stolpovskij Maxim V., Shayakhmetov Airat F., Kochanova Ekaterina Yu., Gaysin Aydar R.   +4 more
doaj   +1 more source

Astronomically paced changes in overturning circulation in the Western North Atlantic during the middle Eocene [PDF]

, 2018
North Atlantic Deep Water (NADW) currently redistributes heat and salt between Earth’s ocean basins, and plays a vital role in the ocean-atmosphere CO2 exchange.
Bickert, Torsten, De Vleeschouwer, David, Harper, Dustin, Kirtland Turner, Sandra, Lohmann, Gerrit, Niezgodzki, Igor, Pälike, Heiko, Sexton, Philip, Vahlenkamp, Maximilian, Zachos, James   +9 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Preformulation investigation and challenges; salt formation, salt disproportionation and hepatic recirculation

European Journal of Pharmaceutical Sciences, 2017
A compound, which is a selective peroxisome proliferator activated receptor (PPAR) agonist, was investigated. The aim of the presented studies was to evaluate the potential of the further development of the compound. Fundamental physicochemical properties and stability of the compound were characterized in solution by liquid chromatography and NMR and ...
Kalle, Sigfridsson, Lena, Nilsson, Matti, Ahlqvist, Thomas, Andersson, Anna-Karin, Granath   +4 more
openaire   +2 more sources

Formation of the Wink Sink, A Salt Dissolution and Collapse Feature, Winkler County, Texas [PDF]

, 1982
UT ...
Baumgardner, Jr., Robert W., Goldstein, Arthur G., Hoadley, Ann D.   +2 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

2-D electrical resistivity tomography assessment of hydrate formation in sandy sediments

Natural Gas Industry B, 2020
Laboratory hydrate formation process simulation provides a theoretical support for determining the dynamic revolution behaviors of actual hydrate reservoirs.
Yanlong Li, Hailiang Sun, Qingguo Meng, Changling Liu, Qiang Chen, Lanchang Xing   +5 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source