Results 41 to 50 of about 1,445,691 (302)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Charge Distribution on Annealed Polyelectrolytes

open access: yes, 1999
We investigate the equilibrium charge distribution along a single annealed polyelectrolyte chain under different conditions. The coupling between the conformation of the chain and the local charge distribution is described for various solvent qualities ...
Castelnovo, Martin   +2 more
core   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Molecular Dynamics Simulation of Membrane Distillation for Different Salt Solutions in Nanopores

open access: yesMolecules
Nanoporous membranes offer significant advantages in direct contact membrane distillation applications due to their high flux and strong resistance to wetting.
Jiadong Li   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

SLS Fabrication of Highly Porous Model Including Fine Flow Channel Network Aiming at Regeneration of Highly Metabolic Organs [PDF]

open access: yes, 2006
Fabrication of very porous scaffold for regeneration of highly metabolic organs is reported. Polycaprolactone (PCL) powder was mixed with fine salt grains as filler and SLS processed to develop a model including fine flow channel network.
Huang, Hongyun   +3 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Constitutive theory of geomaterials saturated with salt solution and its application in clay

open access: yesYantu gongcheng xuebao
The chemical activity of ions in salt solution will change the mechanical properties of saturated geomaterials, inducing geotechnical problems such as deterioration or even failure of engineering properties.
HU Yayuan , YUAN Shuhang
doaj   +1 more source

Analysis of leaves chloride accumulation and phenotypic behavior of nine trifoliate citrus rootstocks under salt stress conditions : [P218] [PDF]

open access: yes, 2008
Citrus in Morocco is mainly grafted on sour orange (Citrus aurantium L.) rootstock which should be abandoned due to its susceptibility to citrus tristeza virus (CTV). Salinity also becomes a serious problem in citrus growing areas of Morocco.
Benazzouz, Abdelkader   +6 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

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