Results 61 to 70 of about 1,445,691 (302)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Yantu gongcheng xuebaoInvestigation on swelling deformation of bentonite infiltrated with salt solutions considering temperature effects is of great significance for design and safely operation of deep geological repositories for disposal of high-level radioactive wastes.
YE Weimin +4 more
doaj +1 more source
Instability of the salinity profile during the evaporation of saline groundwater [PDF]
, 2008 We investigate salt transport during the evaporation and upflow of saline groundwater. We describe a model in which a sharp evaporation-precipitation front separates regions of soil saturated with an air-vapour mixture and with saline water.
ANDREJ T. IL'ICHEV +7 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Scaling Laws of Polyelectrolyte Adsorption
, 1997 Adsorption of charged polymers (polyelectrolytes) from a semi-dilute solution to a charged surface is investigated theoretically. We obtain simple scaling laws for (i) the amount of polymer adsorbed to the surface, Gamma, and (ii) the width of the ...
Andelman, D., Borukhov, I., Orland, H.
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Fermentation in Salt Solution to Produce Jack Beans (Canavalia Ensiformis L) Sauce [PDF]
, 2014 The purpose of this research was to determine the proportion or optimal formulation so as to produce jackbean sauce best quality using Design Expert D‐Optimal method.
Yusman Taufik, Yudi Garnida
core
Self-propulsion of pure water droplets by spontaneous Marangoni stress driven motion
, 2014 We report spontaneous motion in a fully bio-compatible system consisting of pure water droplets in an oil-surfactant medium of squalane and monoolein.
Dauchot, Olivier +3 more
core +3 more sources
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Effects of surface states on salt-frost scaling resistance of cement concrete
Case Studies in Construction Materials, 2019 This study discussed influences of surface states of concrete on salt-frost durability. By using the Capillary suction of Deicing solution and Freeze-thaw test method(CDF), the effects of factors, such as solution saturation in capillary, surface ...
Hui Zhang +3 more
doaj +1 more source