Results 21 to 30 of about 238,220 (255)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Política de Población en el Perú
Acta Médica Peruana, 1978 La dirección de Epidemiología y Programación de la Dirección General de Porgrmas de Salud de Ministerio de Salud, tiene el propósito de hacer conocer la Política de Población en el Perú, Su implementación en el Sector Salud y los progrmas formulados ...
Ministerio de Salud, Dirección de Salud y Población
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FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Salud oral en adolescentes: Escuelas saludables
Revista Científica de Salud UNITEPC, 2022 Introducción: El Índice de CPO-D es uno de los indicadores epidemiológicos más comunes empleado para evaluar la prevalencia de dientes cariados, perdidos y obturados, se define en dentición permanente a partir de los 12 años y según parámetros establecidos es interpretado la severidad; el objetivo es determinar el Índice de CPO-D en los adolescentes de
Teresa Paola Canchari Pereyra +5 more
openaire +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Relación de revisores del año 2018
Revista Peruana de Medicina Experimental y Salud Pública, 2018 -
Rev Peru Med Exp Salud Publica, Instituto Nacional de Salud, Perú
doaj +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
La salud mental en primera persona. Los comités de personas expertas
Revista Española de Discapacidad, 2016 Salud Mental España (2016): “La salud mental en primera persona. Los comités de personas expertas”, Revista Española de Discapacidad, 4 (1): 241-247.
Salud Mental España
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