Results 101 to 110 of about 16,762 (226)
SPG4 and Dementia: Expanding the Clinical Spectrum
Annals of Clinical and Translational Neurology, Volume 13, Issue 10, Page 2002-2016, October 2026.ABSTRACT Objective
Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio +19 morewiley +1 more sourceEssential, Yet Precarious, Mistreated, Sick and Medicalized: A Sequential Explanatory Mixed‐Methods Study on Homecare Aides in Spain
American Journal of Industrial Medicine, Volume 69, Issue 10, Page 814-829, October 2026.ABSTRACT Background
Homecare aides (HCAs) are professional non‐family caregivers, who support dependent individuals to live at home with dignity; yet in Spain they remain understudied and vulnerable, often facing precarious working conditions. We aimed to characterize HCAs’ employment, living conditions, health, and exposure to workplace violence and ...Albert Navarro‐Giné, Pedro Ferrer‐Rosende, Maria Feijoo‐Cid, Sergio Salas‐Nicás, Laura Esteve‐Matalí, Valeria Stuardo‐Ávila, María Isabel Fernández‐Cano +6 morewiley +1 more sourceAir pollution is associated with sex‐specific longitudinal changes in astrocytic and neuroinflammatory processes linked to cognitive decline in Alzheimer's disease at‐risk individuals
Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.Abstract INTRODUCTION
Air pollution is associated with dementia risk, but its role during preclinical Alzheimer's disease (AD) remains unclear. METHODS
We examined long‐term residential exposure to traffic‐related air pollution in 226 cognitively unimpaired middle‐aged individuals at increased risk of AD from the ALzheimer's and FAmilies ALFA+ cohort ...Natalia Vilor‐Tejedor, Blanca Rodríguez‐Fernández, Patricia Genius, Alba Fernández‐Bonet, Armand González‐Escalante, Anna Brugulat‐Serrat, Gonzalo Sanchez‐Benavides, Irene Cumplido‐Mayoral, Carolina Minguillón, Marta Cirach, Mark Nieuwenhuijsen, Gwendlyn Kollmorgen, Clara Quijano‐Rubio, Henrik Zetterberg, Kaj Blennow, Arcadi Navarro, Marc Suárez‐Calvet, Juan Domingo Gispert, for the ALFA study +18 morewiley +1 more sourceTau‐PET correlates of mild behavioral impairment in preclinical and prodromal Alzheimer's disease: A head‐to‐head comparison of Flortaucipir and MK6240
Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.Abstract INTRODUCTION
We compared the association between mild behavioral impairment (MBI) and first‐ versus second‐generation tau‐positron emission tomography (PET) tracers in preclinical and prodromal Alzheimer's disease (AD). METHODS
We assessed 110 individuals with head‐to‐head [18F]MK6240 and [18F]Flortaucipir tau‐PET.Isabella Bizzi, Arthur C. Macedo, Lydia Trudel, Joseph Therriault, Nesrine Rahmouni, Firoza Z. Lussier, Cécile Tissot, Gleb Bezgin, Étienne Aumont, Tevy Chan, Seyyed Ali Hosseini, Delphine Oliva‐Lopez, Marina Pereira Gonçalves, Guilherme Povala, Pamela C. L. Ferreira, Bruna Bellaver, Livia Amaral, Emma Ruppert, Marina Scop Medeiros, Rayan Mroué, Andréia Rocha, Kok Pin Ng, Eduardo R. Zimmer, Joseph Masdeu, Belen Pascual, Val J. Lowe, Hwamee Oh, David N. Soleimani‐Meigooni, Juan Fortea, Zahinoor Ismail, Suzanne Baker, Tharick A Pascoal, Pedro Rosa‐Neto, for the HEAD Study, Cristiano S Aguzzoli, Livia Amaral, Guilherme Bauer‐Negrini, Bruna Bellaver, Ann D Cohen, Alvaro de Oliveira Franco, Douglas T Leffa, Pamela C L Ferreira, Firoza Z Lussier, Marina S Medeiros, Rayan Mroué, Markley S Oliveira, Tharick A Pascoal, Guilherme Povala, Andréia Rocha, Matheus S Rodrigues, Emma Ruppert, Pampa Saha, Juli Singer, Carolina Soares, Dana L Tudorascu, Raphael L Tuma, Suzanne L Baker, Cécile Tissot, Hsin‐Yeh Tsai, Pedro Rosa‐Neto, Tevy Chan, Vladimir Fonov, Yasser Iturria‐Medina, Wan Lu Jia, Jesse Klostranec, Maxime Montembault, Nesrine Rahmouni, Jenna Stevenson, Karine Provost, Paolo Vitali, Selma Avdagic, Emerine Cummings, Brian A Gordon, Danielle Gray, Victoria Tate, Joseph C Masdeu, Belen Pascual, Hwamee Oh, Xiaoyang Hu, Val Lowe, David N Soleimani‐Meigooni, Juan Fortea, Arthur Toga, Tatiana Foroud +83 morewiley +1 more sourceDTI‐ALPS Primarily Reflects White Matter Diffusion Dispersion and Microstructural Heterogeneity in Neurodegeneration: Insights From Multi‐Modal MRI
Human Brain Mapping, Volume 47, Issue 14, October 1, 2026.In a 100‐patient memory‐clinic cohort, DTI‐ALPS was evaluated along with diffusion and microstructural metrics. DTI‐ALPS correlated strongly with mode of anisotropy and orientation dispersion index, and moderately with T1/FLAIR ratio and diamagnetic susceptibility, indicating that DTI‐ALPS mainly reflects white‐matter diffusion complexity rather than ...Luca Sacchi, Giovanni Farruggio, Giorgio Bocca, Tiziana Carandini, Milena De Riz, Laura Ghezzi, Manuela Pintus, Anna Pietroboni, Giacomo Boffa, Elisa Scola, Fabio Triulzi, Marco Bozzali, Daniela Galimberti, Mara Cercignani, Andrea Arighi +14 morewiley +1 more sourceEating Behavior Latent Profiles and Their Associations With Body Composition in Early Childhood: The CORALS Cohort
Obesity, Volume 34, Issue 10, Page 1904-1914, October 2026.ABSTRACT Objective
This study aimed to identify sex‐specific eating behavior profiles and assess the associations between eating behaviors subscales and profiles and body composition indices in Spanish preschoolers from the CORALS cohort. Methods
We conducted a cross‐sectional analysis of baseline data from 1208 children aged 3–6 years (50.1% girls ...Andrea Jimeno‐Martínez, María L. Miguel‐Berges, Ivie Maneschy, Mercedes Gil‐Campos, Rosaura Leis, Nancy Babio, Pilar De Miguel‐Etayo, Santiago Navas‐Carretero, Olga Portolés, Montserrat Fitó Colomer, Cristina Castro‐Collado, Rosaura Picáns‐Leis, Natalia Farré, Miguel Seral‐Cortés, J. Alfredo Martínez, José Jurado‐Castro, Rocío Vázquez‐Cobela, Cristina Rey‐Reñones, Belén Pastor‐Villaescusa, Francisco Llorente‐Cantarero, Karla‐Alejandra Pérez‐Vega, Jordi Salas‐Salvadó, Luis A. Moreno, Guiomar Masip, on behalf of CORALS group +24 morewiley +1 more sourceIneffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?
The Journal of Pathology, Volume 270, Issue 2, Page 139-162, October 2026.Abstract
Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.Giuseppe Schepisi, Irene Torresan, Emilio Francesco Giunta, Sara Bleve, Nicole Brighi, Elisa Tassinari, Sofia Zanuccoli, Maria Concetta Cursano, Cristian Lolli +8 morewiley +1 more source