Results 101 to 110 of about 16,762 (226)

SPG4 and Dementia: Expanding the Clinical Spectrum

open access: yesAnnals of Clinical and Translational Neurology, Volume 13, Issue 10, Page 2002-2016, October 2026.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza   +19 more
wiley   +1 more source

Essential, Yet Precarious, Mistreated, Sick and Medicalized: A Sequential Explanatory Mixed‐Methods Study on Homecare Aides in Spain

open access: yesAmerican Journal of Industrial Medicine, Volume 69, Issue 10, Page 814-829, October 2026.
ABSTRACT Background Homecare aides (HCAs) are professional non‐family caregivers, who support dependent individuals to live at home with dignity; yet in Spain they remain understudied and vulnerable, often facing precarious working conditions. We aimed to characterize HCAs’ employment, living conditions, health, and exposure to workplace violence and ...
Albert Navarro‐Giné   +6 more
wiley   +1 more source

Air pollution is associated with sex‐specific longitudinal changes in astrocytic and neuroinflammatory processes linked to cognitive decline in Alzheimer's disease at‐risk individuals

open access: yesAlzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION Air pollution is associated with dementia risk, but its role during preclinical Alzheimer's disease (AD) remains unclear. METHODS We examined long‐term residential exposure to traffic‐related air pollution in 226 cognitively unimpaired middle‐aged individuals at increased risk of AD from the ALzheimer's and FAmilies ALFA+ cohort ...
Natalia Vilor‐Tejedor   +18 more
wiley   +1 more source

Tau‐PET correlates of mild behavioral impairment in preclinical and prodromal Alzheimer's disease: A head‐to‐head comparison of Flortaucipir and MK6240

open access: yesAlzheimer's &Dementia, Volume 22, Issue 10, October 2026.
Abstract INTRODUCTION We compared the association between mild behavioral impairment (MBI) and first‐ versus second‐generation tau‐positron emission tomography (PET) tracers in preclinical and prodromal Alzheimer's disease (AD). METHODS We assessed 110 individuals with head‐to‐head [18F]MK6240 and [18F]Flortaucipir tau‐PET.
Isabella Bizzi   +83 more
wiley   +1 more source

DTI‐ALPS Primarily Reflects White Matter Diffusion Dispersion and Microstructural Heterogeneity in Neurodegeneration: Insights From Multi‐Modal MRI

open access: yesHuman Brain Mapping, Volume 47, Issue 14, October 1, 2026.
In a 100‐patient memory‐clinic cohort, DTI‐ALPS was evaluated along with diffusion and microstructural metrics. DTI‐ALPS correlated strongly with mode of anisotropy and orientation dispersion index, and moderately with T1/FLAIR ratio and diamagnetic susceptibility, indicating that DTI‐ALPS mainly reflects white‐matter diffusion complexity rather than ...
Luca Sacchi   +14 more
wiley   +1 more source

Restoration of Motility in Acrosome-Reacted Boar Spermatozoa Induced by the Ionophore 4-Br-A23187. [PDF]

open access: yesReprod Domest Anim
ABSTRACT The acrosome reaction (AR) is a calcium‐dependent exocytotic event required for successful fertilization. Calcium ionophores are commonly used to induce AR in vitro; however, this treatment is associated with a significant loss of sperm motility. The aim of this study was to evaluate the recovery of motility in boar spermatozoa after ionophore‐
Martín-Hidalgo D   +3 more
europepmc   +2 more sources

[INFADIMED: 15 years of healthy lifestyle education from primary care. Evolution, results and the role of the community nurse]. [PDF]

open access: yesAten Primaria
Ruiz-Mariscal E   +6 more
europepmc   +1 more source

Eating Behavior Latent Profiles and Their Associations With Body Composition in Early Childhood: The CORALS Cohort

open access: yesObesity, Volume 34, Issue 10, Page 1904-1914, October 2026.
ABSTRACT Objective This study aimed to identify sex‐specific eating behavior profiles and assess the associations between eating behaviors subscales and profiles and body composition indices in Spanish preschoolers from the CORALS cohort. Methods We conducted a cross‐sectional analysis of baseline data from 1208 children aged 3–6 years (50.1% girls ...
Andrea Jimeno‐Martínez   +24 more
wiley   +1 more source

We Salute???

open access: yesAnesthesia & Analgesia, 1963
openaire   +2 more sources

Ineffectiveness of immune checkpoint inhibitors in prostate cancer: is it just a question of ‘‐mabs’?

open access: yesThe Journal of Pathology, Volume 270, Issue 2, Page 139-162, October 2026.
Abstract Prostate cancer (PCa) is the second most common type of neoplasm, currently treated with a variety of therapeutic agents. Although advances in treatment over the past decade have improved overall survival, patients with advanced PCa eventually progress from hormone‐sensitive PCa to metastatic castration‐resistant PCa.
Giuseppe Schepisi   +8 more
wiley   +1 more source

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