Results 41 to 50 of about 38,798,065 (214)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Pomorskopravni institut uklanjanja podrtina - koncepcijska razmatranja i kritika pravnog uređenja u hrvatskom pomorskom pravu

Poredbeno Pomorsko Pravo, 2011
Autorice elaboriraju odgovore na pitanja koncepcijske prirode vezane uz institut uklanjanja podrtina. Nakon, detaljne analize i tumačenja relevantnih pojmova, komparativnom metodom proučavaju se i uspoređuju instituti vađenja potonulih stvari, uklanjanja
Adriana Vincenca Padovan, Vesna Skorupan Wolff   +1 more
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Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Nagrada za spašavanje - pouka o pravu na preinačenje tužbenog zahtjeva : [prikaz presude i bilješka]

Uporedno pomorsko pravo, 1990
Ako tuženik nije ujedno i vlasnik spašenoga broda, nagradu za spašavanje duguje vlasnik odnosno korisnik broda. Ta obveza se temelji na stvarnopravnom zahtjevu, a na propisima o privilegijima.
Gordana Gasparini, Branko Jakaša
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Pier pressure: 23 years of incidental sea turtle captures at recreational fishing piers along Florida’s Gulf coastline

Frontiers in Marine Science
Incidental captures of sea turtles during fishing activities affect their populations worldwide. Previous research has documented the impacts of commercial fisheries in nearshore and offshore waters, and research-based minimization measures are now ...
Robby J. Brannum, Karrie Minch, Morgan Wideroff, Meghan E. Koperski, Colin P. Shea, Allen M. Foley, Robbin N. Trindell   +6 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Konačni nacrt nove konvencije o spašavanju na moru i rješenja koja on donosi

Uporedno pomorsko pravo, 1989
Premda je Konvencija o spašavanju na moru iz 1910. godine jedan od najšire prihvaćenih unifikacijskih akata iz područja pomorskog imovinskog prava, vremenom se javila potreba da se izradi novi suvremeniji dokument.
Predrag Stanković
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Studies of indigenous lithic procurement in Uruguay and their implications for Southern Cone archaeology

Journal of Lithic Studies, 2016
Being a territory with several minerals and rocks suitable for knapping and grinding, Uruguay offered a lithic-rich environment for past indigenous cultures in the Southern Cone of South America.
Arlys Nicolás Batalla
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Hrvatsko pravo spašavanja u uvjetima europskih integracija

Poredbeno Pomorsko Pravo, 2007
Rad se bavi ulogom spašavatelja u zaštiti morskog okoliša te položajem profesionalnih spašavatelja u EU i RH. Važnost spašavanja u okviru zaštite morskog okoliša raste iz godine u godine. Tek 1980.
Ranka Petrinović, Bisera Plančić
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