Results 21 to 30 of about 38,798,065 (214)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
U radu se analiziraju odredbe o spašavanju i vađenju potonulih stvari u novom Pomorskom zakoniku Republike Hrvatske. Navode se razlozi za anticipirani hrvatski prihvat nove Međunarodne konvencije o spašavanju iz 1989., koja inače još nije stupila na ...
Predrag Stanković
doaj
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Isplata nagrade za spašavanje : [prikaz presude]
Svaki član posade broda spašavatelja može podnijeti tužbu za isplatu pripadajućeg mu dijela nagrade za spašavanje protiv brodara spašenoga broda, pod uvjetom da brodar broda spašavatelja nije podnio tužbu za isplatu nagrade.
Jasenko Marin
doaj
At the international level there have been international conventions that accommodate the regulation of historic sinking vessels, although only in general, namely the 1982 United Nations Convention on the Law of the Sea (UNCLOS 1982), Convention on the ...
Muhammad Nur
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Zakon o traganju i spasavanju na moru - de lege ferenda
Materija traganja i spasavanja na moru, u delu koji se odnosi na javnopravni, odnosno upravno-pravni aspekt spasavanja lica i stvari u obalnom moru SFRJ nije dovoljno uređena kako saveznim, tako i republičkim propisima.
Miloje Todorić
doaj
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Nova međunarodna konvencija o spašavanju na moru
Na Diplomatskoj konferenciji, održanoj u travnju 1989. u Londonu, usvojena je nova Međunarodna konvencija o spašavanju na moru. Ta će Konvencija zamijeniti Međunarodnu konvenciju o spašavanju i pružanju pomoći na moru, usvojenu u Briselu 1910.
Predrag Stanković
doaj

