Results 51 to 60 of about 58,653 (282)

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Realist review of managed alcohol programmes for people experiencing alcohol dependence and homelessness: what works, for whom, and in what circumstances?

Harm Reduction Journal
Introduction People experiencing homelessness and alcohol dependence are vulnerable to a range of harms, and existing treatment options, which are often abstinence-based, are inadequate for this group because they may be unavailable, unsuitable, or not ...
Hannah Carver, Emma King, Jessica Greenhalgh, Gillian W. Shorter, Bernie Pauly, Tessa Parkes   +5 more
doaj   +1 more source

RETRACTED: The impact of agricultural water salvation investment on economics development: Evidence from Eastern China.

PLoS ONE, 2022
Agricultural water salvation is the lifeblood of the national economy and is of great significance to the high-quality development of the region. In order to maximize the economic assistances of agricultural water salvation investment, this article ...
Haofeng Lin, Houyem Zrelli, Noha Hassan Abd Algalil Mohamed, Yonghui Li, Mohammad Mahtab Alam, Wei Guo, Yousaf Ali Khan   +6 more
doaj   +1 more source

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Highly Conductive and Transparent Coatings via Low‐Temperature Hydroiodic Acid Vapor Treatment of Oxo‐Graphene Thin Films

Advanced Materials Technologies, EarlyView.
The double self‐assembly (DSA) method applied to oxo‐graphene (oxo‐G) flakes followed by hydroiodic acid (HI) vapor treatment and low‐temperature annealing yields highly conductive, optically transparent thin films with the potential for applications in electronic and optoelectronic devices.
Arindam Konar, David Kaiser, Guobin Jia, Hamid Reza Rasouli, Janis Köster, Christof Neumann, Andrea Dellith, Uwe Hübner, Christian E. Halbig, Siegfried Eigler, Ute Kaiser, Benjamin Dietzek‐Ivanšić, Jonathan Plentz, Andrey Turchanin   +13 more
wiley   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

[News Clip: Salvation Army]

, 1958
Video footage from the WBAP-TV station in Fort Worth, Texas to accompany a news story about the Salvation Army's toy store in Fort ...
WBAP-TV (Television station : Fort Worth, Tex.)
core   +1 more source

Obesity and Gut Microbiota: a Succinct Evaluation

International Journal on Food, Agriculture and Natural Resources
Obesity has been of global health concern, contributing to a wide range of chronic diseases such as cardiovascular disease, type 2 diabetes, and certain cancers.
Evidence Anujem, Salvation Anujem
doaj   +1 more source

Glutaminolysis Blockade‐Empowered Bimodal Nanodepot for Spatially Complementary Sono‐Thermal Ablation via PANoptosis and STING Activation Against Large Tumors

Advanced Science, EarlyView.
An injectable bimodal TCPD nanodepot disrupts glutaminolysis and TCA metabolism, sensitizing large tumors to spatially complementary sono‐thermal ablation for complete treatment coverage. This intervention induces mitochondrial and endoplasmic reticulum dysfunction, genotoxicity, and NAD+ depletion, converging to trigger PANoptosome assembly and ...
Yi‐Ming Liu, Juan Qin, Si‐Yuan Wu, Xue‐Zhen Zhu, Yun‐Fei Cai, Pei‐Yao Sun, Hao Yang, Xing‐Yue Wang, Shu Li, Duo Wang, Hai‐Dong Zhu   +10 more
wiley   +1 more source

Interpretations of Annex 7: assessing the impact on non-returnees in the UK

Forced Migration Review, 2015
Emphasising the crucial role of refugee returns to the future of Bosnia and Herzegovina risks minimising the agency of those who choose not to exercise their rights under Annex 7.
Gayle Munro
doaj