Results 31 to 40 of about 57,012 (282)

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Health Information: Applications and challenges in the COVID-19 pandemic

Asia Pacific Journal of Health Management, 2020
Global health systems are under immense pressure with the exponential growth and spread of COVID-19.  Public health and health system responses to the pandemic have relied on health information reporting, visualisation, and projections of incidence ...
Sheree Lloyd, Sue M Walker, Ani Goswami
doaj   +1 more source

A peer-delivered intervention to reduce harm and improve the well-being of homeless people with problem substance use: the SHARPS feasibility mixed-methods study

Health Technology Assessment, 2022
Background: For people experiencing homelessness and problem substance use, access to appropriate services can be challenging. There is evidence that development of trusting relationships with non-judgemental staff can facilitate service engagement. Peer-
Tessa Parkes, Catriona Matheson, Hannah Carver, Rebecca Foster, John Budd, Dave Liddell, Jason Wallace, Bernie Pauly, Maria Fotopoulou, Adam Burley, Isobel Anderson, Graeme MacLennan   +11 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Realist review of nature-based interventions for men: understanding the contexts and mechanisms necessary for successful outcomes

BMC Public Health
Background Men face significant health disparities, including higher rates of premature death, mental health challenges, and substance use disorders. Nature-based interventions hold promise for improving men’s health and wellbeing by leveraging natural ...
Josh Dumbrell, W Masterton, H Carver, T Parkes   +3 more
doaj   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

Ways of Salvation and the Way of Salvation

, 2019
Abstract: Every religion offers salvation or liberation. Since the time of Cyprian of Carthage, the Catholic Church held the exclusive Christian claim that there is no salvation outside the Church (Extra Ecclesiam nulla salus). However, at the Vatican II there was a re-visioning and a renewed understanding of salvation that that went beyond absolute ...
openaire   +3 more sources

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source

Realist review of managed alcohol programmes for people experiencing alcohol dependence and homelessness: what works, for whom, and in what circumstances?

Harm Reduction Journal
Introduction People experiencing homelessness and alcohol dependence are vulnerable to a range of harms, and existing treatment options, which are often abstinence-based, are inadequate for this group because they may be unavailable, unsuitable, or not ...
Hannah Carver, Emma King, Jessica Greenhalgh, Gillian W. Shorter, Bernie Pauly, Tessa Parkes   +5 more
doaj   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source