Results 41 to 50 of about 41,152 (290)

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Realist review of managed alcohol programmes for people experiencing alcohol dependence and homelessness: what works, for whom, and in what circumstances?

Harm Reduction Journal
Introduction People experiencing homelessness and alcohol dependence are vulnerable to a range of harms, and existing treatment options, which are often abstinence-based, are inadequate for this group because they may be unavailable, unsuitable, or not ...
Hannah Carver, Emma King, Jessica Greenhalgh, Gillian W. Shorter, Bernie Pauly, Tessa Parkes   +5 more
doaj   +1 more source

We want the good life now

Ecclesial Futures, 2022
While late-modern people in contemporary western societies may be curi­ous about salvation and have questions regarding the hereafter, they clearly long to achieve human flourishing here and now.
Dejan Aždajić
doaj   +1 more source

Ways of Salvation and the Way of Salvation

, 2019
Abstract: Every religion offers salvation or liberation. Since the time of Cyprian of Carthage, the Catholic Church held the exclusive Christian claim that there is no salvation outside the Church (Extra Ecclesiam nulla salus). However, at the Vatican II there was a re-visioning and a renewed understanding of salvation that that went beyond absolute ...
openaire   +3 more sources

Reinnervation of Muscle Targets Enhances the Separability of Motor Unit Signals Following Peripheral Nerve Transfers

Advanced Science, EarlyView.
Injured or cut peripheral nerves can be surgically rerouted to reinnervate new muscle targets. This study demonstrates reinnervated muscles exhibit enhanced separability between individual motor unit signals, which can simplify signal recording and decomposition. These findings highlight the potential of reinnervated muscle to serve as a key biological
Kiara N Quinn, Siyu Wang, Lang Qin, Alessandro Ascani Orsini, Kenzi Griffith, Rachana Suresh, Fausto Kang, Pierce L Perkins, Neha Joshi, Alexis L Lowe, Sami Tuffaha, Nitish V Thakor   +11 more
wiley   +1 more source

Obesity and Gut Microbiota: a Succinct Evaluation

International Journal on Food, Agriculture and Natural Resources
Obesity has been of global health concern, contributing to a wide range of chronic diseases such as cardiovascular disease, type 2 diabetes, and certain cancers.
Evidence Anujem, Salvation Anujem
doaj   +1 more source

al-Ġazālī on the Problem of Salvation [PDF]

پژوهشنامه فلسفه دین, 2018
The nature of salvation, the path leading to it and its different degrees, and determining those who will attain salvation are important issues which scholars and theologians of various traditions, have tried to answer.
Mohammad Tavakkolipoor
doaj   +1 more source

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, EarlyView.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source