Results 41 to 50 of about 58,653 (282)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Salvation

ACM SIGGRAPH 2026 Computer Animation Festival
Abstract At its best, Baptist soteriology emphasizes the cross and the resurrection as the heart of God’s work of salvation, while holding closely to the entire life and ministry of Jesus Christ and its resonances for the transformative work of the Holy Spirit now.
  +8 more sources

A peer-delivered intervention to reduce harm and improve the well-being of homeless people with problem substance use: the SHARPS feasibility mixed-methods study

Health Technology Assessment, 2022
Background: For people experiencing homelessness and problem substance use, access to appropriate services can be challenging. There is evidence that development of trusting relationships with non-judgemental staff can facilitate service engagement. Peer-
Tessa Parkes, Catriona Matheson, Hannah Carver, Rebecca Foster, John Budd, Dave Liddell, Jason Wallace, Bernie Pauly, Maria Fotopoulou, Adam Burley, Isobel Anderson, Graeme MacLennan   +11 more
doaj   +1 more source

Augustine and Pelagius View on Salvation: Salvation by Grace or Works [PDF]

, 2021
Salvation is a crucial part of a Christian's life. There are several interpretations according to the term of salvation. We are saved by grace and through faith and our salvation is the gift from God, but the questions arise, if salvation is given by God,
Kasingku, Juwinner Dedy
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Realist review of nature-based interventions for men: understanding the contexts and mechanisms necessary for successful outcomes

BMC Public Health
Background Men face significant health disparities, including higher rates of premature death, mental health challenges, and substance use disorders. Nature-based interventions hold promise for improving men’s health and wellbeing by leveraging natural ...
Josh Dumbrell, W Masterton, H Carver, T Parkes   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Geopolitics and The Role of The Church in Nationalism on Daily Basis in the 21st Century

Evangelikal: Jurnal Teologi Injili dan Pembinaan Warga Jemaat, 2023
Through empirical knowledge, articles, papers, and a daily basis of field observation, this paper proposes an analysis of the current trend on how people usually have pride and a good sense of nationalism towards their nation.
Fredric Novando Suhartono, Martina Novalina, Indria Samego, Andri Pasaribu, Sidney Salcido   +4 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Ways of Salvation and the Way of Salvation

, 2019
Abstract: Every religion offers salvation or liberation. Since the time of Cyprian of Carthage, the Catholic Church held the exclusive Christian claim that there is no salvation outside the Church (Extra Ecclesiam nulla salus). However, at the Vatican II there was a re-visioning and a renewed understanding of salvation that that went beyond absolute ...
openaire   +3 more sources