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Functionalized biomimetic nanoparticles loaded with salvianolic acid B for synergistic targeted triple-negative breast cancer treatment. [PDF]

Mater Today Bio
Cheng N, Zhou Q, Jia Z, Mu Y, Zhang S, Wang L, Chen Y.   +6 more
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Dynamic extraction process of salvianolic acids

China Journal of Chinese Materia Medica, 2010
To optimize the dynamic extraction process of salvianolic acids.Salvianolic acids was selected as index. The effects of extraction temperature, granularity, solvent multiple, circle value and extraction time were studied on the process of dynamical extraction.
Lingqiao, Lu, Yongchuan, Zhou, Xian, Chen, Min, Zhang, Jieting, Dai   +4 more
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Formal total synthesis of salvianolic acid N

Organic & Biomolecular Chemistry, 2018
Salvianolic acid N was synthesized starting from 3,4-dimethoxybenzaldehyde in 11 steps and with an overall yield of 11%. The key reaction steps were the Wittig reaction for Z-stereoselectivity, the copper catalyzed intramolecular cyclization for seven membered ring skeleton, and the deprotected allylic group with Pd catalysis.
Kong Wu, Zhong Pao Xie, Dong-Mei Cui, Chen Zhang   +3 more
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Research progress on salvianolic acids of Salvia miltiorrhiza

China Journal of Chinese Materia Medica, 2016
Salvia miltiorrhiza is one of the most common traditional Chinese medicines. It has rich resources in China. According to modern studies, phenolic acids are the main effective components in S. miltiorrhiza. These components have cardiovascular and cerebrovascular protective effect, and anti-tumor, antioxidant, anti-inflammatory, and antifibrotic ...
Wen-Yi, Liang, Wen-Jing, Chen, Guang-Hui, Yang, Dan, Zhu, Xin, Mao, Yan-Yan, Shao, Ling-Fang, Wu, Xiao-Xue, Zhang, Lan-Zhen, Zhang   +8 more
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Antiplatelet and antithrombotic activities of salvianolic acid A

Thrombosis Research, 2010
Salvianolic acid A (SAA), the water-soluble phenolic acids in Salvia miltiorrhiza, has shown the most potent bioactivities, including protection against cerebral lesion, defense from oxidative damage and improvement of remembrance. In the present study, we studied the antiplatelet and antithrombotic effects of a newly synthesized SAA with different ...
Hua-Ying, Fan, Feng-Hua, Fu, Ming-Yan, Yang, Hui, Xu, Ai-Hong, Zhang, Ke, Liu   +5 more
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Bioavailability of salvianolic acid B and effect on blood viscosities after oral administration of salvianolic acids in beagle dogs

Archives of Pharmacal Research, 2009
Salvianolic acid B (SalB) is an active component isolated from Chinese herbal medicine Salvia miltiorrhiza. The aim of this study was to investigate the extent of absolute oral bioavailability (F) of SalB in beagle dogs and the effect on blood viscosity after intravenous and oral administration of Salvianolic acids (SAs). A gradient elution HPLC method
Dong-Yan, Gao, Li-Mei, Han, Li-Hong, Zhang, Xiao-Ling, Fang, Jian-Xin, Wang   +4 more
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The total synthesis of salvianolic acid F

Tetrahedron, 1999
Abstract An expeditious synthesis of salvianolic acid F 2 is described in 10% overall yield. Tetramethyl salvianolic acid F 3 was obtained in six steps in 39% overall yield and was converted into the target molecule using boron tribromide in 26% yield.
Vincent Dalla, Philippe Cotelle
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A quality marker study on salvianolic acids for injection

Phytomedicine, 2018
The quality of Chinese medicine (CM) has being an active and challenging research area for CM. Prof. Chang-Xiao Liu et al first proposed the concept of quality marker (Q-Marker) for the quality evaluation and control on CM. This article describe the exploratory studies of Q-Marker in salvianolic acids for injection (SAI) based on this new concept.This ...
Wei, Li, Navaneethakrishnan, Polachi, Xiangyang, Wang, Yang, Chu, Yuan, Wang, Meng, Tian, Dekun, Li, Dazheng, Zhou, Shuiping, Zhou, Aichun, Ju, Yubo, Li, Yanjun, Zhang, Min, Chen, Luqi, Huang, Changxiao, Liu   +14 more
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Research progress of salvianolic acid A

China Journal of Chinese Materia Medica, 2011
Salvianolic acid A is a water-soluble component from Danshen, which is frequently used in traditional Chinese medicine. High performance liquid chromatography was often used to analyze content of salvianolic acid A. The yield of salvianolic acid A increased by the technological improvement of extraction and separation.
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Synthesis of (+)-salvianolic acid A from sodium Danshensu

Tetrahedron, 2018
Abstract (+)-Salvianolic acid A, one of the most active components in the traditional Chinese medicine Danshen, has been synthesized over 10 steps in 6.5% overall yield. Starting from inexpensive ortho-vanillin and sodium Danshensu (synthesized via asymmetric catalysis in our group), the process consists of the following: A Wittig reaction that gives
Kai Xu, Hao Liu, Delong Liu, Cheng Sheng, Jiefeng Shen, Wanbin Zhang   +5 more
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