Results 211 to 220 of about 929,762 (263)

The asymmetric total synthesis of (+)-salvianolic acid A

Tetrahedron, 2016
Abstract An asymmetric synthesis of (+)-salvianolic acid A with cardioprotective properties, has been accomplished in a convergent manner in eight steps and 10.6% overall yield. This synthesis features an asymmetric addition of organometallics to optically pure 2,3-epoxypropionate in the presence of BF3·Et2O, Ru(III)-catalyzed directed C H ...
Yong Zheng, Wei-Bin Song, Li-Jiang Xuan
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Salvianolic acid J, a depside from Salvia flava

Phytochemistry, 1994
Abstract A new depside, salvianolic acid J, was isolated from an aqueous extract of Salvia flava as a trace component, together with salvianolic acids A and B. The major component was rosmarinic acid.
Chun-Bo Ai, Qiao-Hong Deng, Wan-Zhi Song, Lian-Niang Li   +3 more
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Salvianolic Acid I: A New Depside fromSalvia cavaleriei

Planta Medica, 1994
A new depside named salvianolic acid I was isolated from the aqueous extract of SALVIA CAVALERIEI, along with salvianolic acids A, B, C, H, isosalvianolic acid C, lithospermic acid, and rosmarinic acid. The chemical struktures were determined by spectral analysis.
H J, Zhang, L N, Li
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Metal-organic framework composites-based molecularly imprinted polymers functionalized with deep eutectic solvent for selective extraction of Salvianolic acid A from Salvia miltiorrhizae Radix.

Journal of Chromatography A
Efficient and selective enrichment of Salvianolic acid (SAA) from natural herbs is a promising approach with substantial potential for practical applications. Therefore, SiO2@UiO-66@DESs@MIPs was synthesized by using in-situ generated MOF particles (SiO2@
Yanhua Sun, Shuang Shang, Xiangyang Kong, Yaheng Zhang, Zihan Liu, Kaijia Wang, Zhiyu Xie   +6 more
semanticscholar   +1 more source

Exploring the anti-amyloid potential of salvianolic acid A against the ALS-associated mutant SOD1: insights from molecular docking and molecular dynamic simulations

Molecular Simulation
A central feature of a variety of related neurological disorders, including amyotrophic lateral sclerosis (ALS), is the deposition of misfolded protein aggregates in key regions of the human brain.
Zainab Abdullah Waheed, Bagher Seyedalipour, Abasalt Hosseinzadeh Colagar, Payam Baziyar   +3 more
semanticscholar   +1 more source

Protective effects of salvianolic acid A on clozapine‐induced cardiotoxicity in zebrafish

Journal of Applied Toxicology, 2022
AbstractThe clinical use of clozapine (CLZ), an atypical antipsychotic drug, was affected by side effects, such as cardiotoxicity. We selected normally developing zebrafish embryos to explore the antagonism of salvianolic acid A (SAA) against clozapine‐induced cardiotoxicity. Embryos were treated with CLZ and SAA, and zebrafish phenotypes were observed
Shenghua Lin, Cailian Mo, Luyi Yan, Feng Zhang, Xin Liu, Honglin Ma, Chuanlin Shen, Wei Fan, Kechun Liu, Qing Zhu, Qiuxia He   +10 more
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Salvianolic acid A suppresses MMP-2 expression and restrains cancer cell invasion through ERK signaling in human nasopharyngeal carcinoma.

Journal of Ethnopharmacology, 2020
ETHNOPHARMACOLOGICAL RELEVANCE Salvia miltiorrhiza Bunge, as known as Danshen, has used for the prevention and treatment of cardiovascular diseases clinically and anti-cancer activities.
C. Chuang, Yung-chuan Ho, Chiao-Wen Lin, Wei-En Yang, Yung-Luen Yu, M. Tsai, Shun-Fa Yang, S. Su   +7 more
semanticscholar   +1 more source

Research progress of salvianolic acid A

China Journal of Chinese Materia Medica, 2011
Salvianolic acid A is a water-soluble component from Danshen, which is frequently used in traditional Chinese medicine. High performance liquid chromatography was often used to analyze content of salvianolic acid A. The yield of salvianolic acid A increased by the technological improvement of extraction and separation.
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Salvianolic Acid A, a New Depside from Roots ofSalvia miltiorrhiza

Planta Medica, 1984
A new depside of D-(+)-beta-(3,4-dihydroxyphenyl)-lactic acid and 2-(3,4-dihydroxyphenylethenyl)-caffeic acid, named salvianolic acid A, was isolated from the dried roots of SALVIA MILTIORRHIZA Bunge. Its chemical structure was defined by spectral analysis and chemical degradation.
L, Lian-Niang, T, Rui, C, Wei-Ming
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Salvianolic acid A inhibits tumor-associated angiogenesis by blocking GRP78 secretion

Naunyn-Schmiedeberg's Archives of Pharmacology, 2018
Glucose-regulated protein 78 (GRP78) often highly expresses in a wide range of tumors, which plays promotive functions due to its diversity of location in the development of tumor. Particularly, GRP78 can be secreted into microenvironment by tumor cells through the pathway of exosome, which promotes proliferation, angiogenesis, and drug resistance in ...
Yufei, Yang, Lichao, Zhang, Xiaoqin, La, Zhuoyu, Li, Hanqing, Li, Songjia, Guo   +5 more
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