Results 191 to 200 of about 19,711 (218)

Salvianolic acid L, a potent phenolic antioxidant from Salvia officinalis

Tetrahedron Letters, 2001
Abstract Salvianolic acid L, a rosmarinic acid dimer, was isolated from Salvia officinalis and identified as 7,8-dihydroxy-2-(3,4-dihydroxyphenyl)-1,2-dihydronaphthalene-1,3-dicarboxylic acid di(1-carboxy-2-(3,4-dihydroxyphenyl))ethyl ester. Two novel hydrolytic products 7,8-dihydroxy-2-(3,4-dihydroxyphenyl)-1,2-dihydronaphthalene-1,3-dicarboxylic ...
Yinrong Lu, L.Yeap Foo
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Metabolism of Salvianolic Acid A and Antioxidant Activities of Its Methylated Metabolites

Drug Metabolism and Disposition, 2014
This study investigated the metabolism of salvianolic acid A (SAA) both in vivo and in vitro. Liquid chromatography-mass spectrometry analysis of drug-containing rat bile samples and bile samples hydrolyzed by glucuronidase revealed a series of methylated conjugates of SAA and its glucuronides, as well as the predominance of the methylation pathway of ...
Hui, Xu, Yanli, Li, Xin, Che, Hongcui, Tian, Huaying, Fan, Ke, Liu   +5 more
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Rapid and simultaneous determination of salvianolic acid A and salvianolic acid B by complex chromatography and study on related mechanism of coordination

Analytica Chimica Acta, 2008
Abstract Salvianolic acid A (Sal A) and salvianolic acid B (Sal B) are water-soluble phenolic acids in Danshen extract and they have high medicinal value. A rapid and novel complex high-performance liquid chromatography (HPLC) method has been developed and validated for the simultaneous determination of Sal A and Sal B within 10 min.
Beibei Zhou, Jian Pan, Jia Wang
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Cerebral Protection of Salvianolic Acid A by the Inhibition of Granulocyte Adherence

The American Journal of Chinese Medicine, 2011
Ischemic stroke is one of the most common causes of death and disability that is induced by ischemia reperfusion (IR). Granulocyte adherence has been proven to be a principal cause of IR. Salvianolic acid A (Sal A) is one of the major active components of Danshen, a Chinese herbal medicine used for the treatment of cardiovascular and cerebrovascular ...
Min, Jiang, Xiao-Ying, Wang, Wang-Yi, Zhou, Jing, Li, Jie, Wang, Li-Ping, Guo   +5 more
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Preparation of salvianolic acid A by the degradation reaction of salvianolic acid B in subcritical water integrated with pH-zone-refining counter-current chromatography

Journal of Chromatography A, 2016
Salvianolic acid A is the major bioactive compound in Danshen, however, due to the chemical instability and low content in Danshen, it is difficult to extract amount of salvianolic acid A. Therefore, this study was to establish an effective strategy for obtaining adequate amount of salvianolic acid A, subcritical water extraction was used to degrade ...
Huaizhi, Li, Yan, Cheng, Hongjing, Dong, Xiao, Wang, Jia, Li, Qianshan, Gao   +5 more
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Protection by salvianolic acid A against adriamycin toxicity on rat heart mitochondria

Free Radical Biology and Medicine, 1992
It was found that salvianolic acid A (Sai A) has potent antioxidant activity. The effects of Sai A on adriamycin-induced heart mitochondrial toxicity of rats in vitro and on adriamycin antitumor activity are investigated in this article. Malondialdehyde (MDA) formation and membrane rigidification of rat heart mitochondria intoxicated with adriamycin ...
T J, Lin, G T, Liu, Y, Liu, G Z, Xu
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Transformation of Salvianolic Acid B to Salvianolic Acid A in Aqueous Solution and the In Vitro Liver Protective Effect of the Main Products

Journal of Food Science, 2014
Abstract Salvianolic acid A (Sal A) was considered to be the compound with highest activity in Salvia miltiorrhiza (danshen). Due to its low content in raw materials, many studies reported its preparation from salvianolic acid B (Sal B).
Shidong, Kan, Zhouzhou, Chen, Lei, Shao, Ji'an, Li   +3 more
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Cardioprotective effect of salvianolic acid A on isoproterenol-induced myocardial infarction in rats

European Journal of Pharmacology, 2009
The present study was designed to evaluate the cardioprotective potential of salvianolic acid A on isoproterenol-induced myocardial infarction in rats. Hemodynamic parameters and lead II electrocardiograph were monitored and recorded continuously. Cardiac marker enzymes and antioxidative parameters in serum and heart tissues were measured.
Shou-bao, Wang, Shuo, Tian, Fan, Yang, Hai-guang, Yang, Xiu-ying, Yang, Guan-hua, Du   +5 more
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Chinese Medicine-Derived Salvianolic Acid B for Disease Therapy: A Scientometric Study

The American Journal of Chinese Medicine
Salvianolic acid B (SalB), among the most abundant bioactive polyphenolic compounds found in Salvia miltiorrhiza Bge., exerts therapeutic and protective effects against various diseases. Although some summaries of the activities of SalB exist, there is lack of a scientometric and in-depth review regarding disease therapy.
Meina Zhao, Fei Mu, Rui Lin, Kai Gao, Wei Zhang, Xingru Tao, Dong Xu, Jingwen Wang   +7 more
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[Research on Molecular Spectra of Interactions Between Salvianolic Acid A and Salvianolic Acid B with Insulin, and Effect of Glucose on the Binding].

Guang pu xue yu guang pu fen xi = Guang pu, 2018
The interactions of Salvianolic acis A (SAA) and Salvianolic acid B (SAB) with insulin were studied by using fluorescence spectroscopy, UV-vis spectroscopy and ATR-FTIR spectroscopy in simulating physiological condition (pH 7.40). The fluorescence quenching of insulin by SAA and SAB were static quenching process.
Wen-yue, Yang, Lin, Cui, Ling-ling, Qu, Ning, Xu, Yun, Huang, Li-jian, Cui, Wen-hong, Zhan, Ding, Zhao   +7 more
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