Results 81 to 90 of about 929,762 (263)

Activation of AMP-Activated Protein Kinase-Sirtuin 1 Pathway Contributes to Salvianolic Acid A-Induced Browning of White Adipose Tissue in High-Fat Diet Fed Male Mice

Frontiers in Pharmacology, 2021
Background: Salvianolic acid A (Sal A), a natural polyphenolic compound extracted from Radix Salvia miltiorrhiza (Danshen), exhibits exceptional pharmacological activities against cardiovascular diseases.
Jianfei Lai, Jianfei Lai, Qianyu Qian, Qianyu Qian, Qinchao Ding, Qinchao Ding, Qinchao Ding, Li Zhou, Ai Fu, Zhongyan Du, Cui Wang, Cui Wang, Zhenyuan Song, Songtao Li, Songtao Li, Xiaobing Dou, Xiaobing Dou   +16 more
doaj   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Phytochemicals and bioactive properties of Ilex paraguariensis: an in-vitro comparative study between the whole plant, leaves and stems [PDF]

, 2015
Leaves, stems and whole plant of Ilex paraguariensis (yerba mate) were characterized in terms of their chemical composition and biological activities in order to determine which part of the plant is more interesting to develop bioactive formulations. The
Barros, Lillian, Bracht, Adelar, Calhelha, Ricardo C., Corrêa, Rúbia C.G., Ferreira, Isabel C.F.R., Matsushita, Makoto, Peralta, Rosane M., Santos-Buelga, Celestino, Souza, Aloisio Henrique Pereira de   +8 more
core   +1 more source

Salvianolic Acid A Ameliorates Early-Stage Atherosclerosis Development by Inhibiting NLRP3 Inflammasome Activation in Zucker Diabetic Fatty Rats

Molecules, 2020
Salvianolic acid A (SAA), an important bioactive polyphenolic acid found in Salvia miltiorrhiza Bunge, may be used for treating metabolic disorders due to its anti-inflammatory activity.
Quanxin Ma, Qinqin Yang, Jiaojiao Chen, Chen Yu, Lizong Zhang, Weimin Zhou, Minli Chen   +6 more
semanticscholar   +1 more source

Salvianolic acid-A alleviates oxidative stress-induced osteoporosis

Life Sciences
Cellular damage induced by oxidative stress contributes to systemic bone disorders leading to osteoporosis. Bone homeostasis regulates the balance between the functions of osteoblasts and osteoclasts. Osteoblast cells are responsible for bone formation and are very sensitive to oxidative stress.
Ayaan, Khan, Hope, Sabella, Venkata Kiran Kumar, Mandlem, Farah, Deba   +3 more
openaire   +2 more sources

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, EarlyView.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

Effects of gamma irradiation on cytotoxicity and phenolic compounds of Thymus vulgaris L. and Mentha x piperita L. [PDF]

, 2016
The aim of the present study was to evaluate the effects of gamma irradiation on cytotoxicity and phenolic compounds of Thymus vulgaris L. and Menta × piperita L. (methanolic extracts), used in traditional medicine.
Antonio, Amilcar L., Barros, Lillian, Cabo Verde, Sandra, Calhelha, Ricardo C., Ferreira, Isabel C.F.R., Pereira, Eliana, Pimenta, Andreia I., Santos-Buelga, Celestino   +7 more
core   +1 more source

Approaching Scarless Wound Healing: From Passive Anti‐Fibrotic to Proactive and Programmable Pro‐Regenerative Strategies

Advanced Science, EarlyView.
This review outlines the wound healing process and factors influencing scar formation, explores how certain animals and human fetuses achieve scarless skin or tissue regeneration, and details tissue engineering material strategies employed in scarless wound dressings.
Meimei Fu, Zhuoyi Huang, Jintao Li, Yue Li, Zhou Fang, Yiwen Jiang, Keke Wu, Jinshan Guo   +7 more
wiley   +1 more source

Salvianolic acid a inhibits platelet activation and aggregation in patients with type 2 diabetes mellitus

BMC Cardiovascular Disorders, 2020
BackgroundPlatelets in patients with type 2 diabetes mellitus (DM2) are characterized by increased activation and aggregation, which tends to be associated with a high morbidity and mortality due to cardiovascular disease (CVD).
Aiming Zhou, Yijia Xiang, En-Qian Liu, Changhong Cai, Yonghui Wu, Lebing Yang, Chun-lai Zeng   +6 more
semanticscholar   +1 more source

Cutting edge strategies for diabetic wound care: Nanotechnology, bioengineering, and beyond

BMEMat, EarlyView.
Graphical abstract illustrates the challenges in diabetic wound healing, covering pathophysiology, formulation hurdles, and emerging therapeutic strategies. It highlights the role of hyperglycemia, formulation complexities, and advanced technologies like bioprinting and AI in improving diabetic wound management. Abstract Diabetic wounds affect millions
Usama Ahmad, Wan Nurhidayah Wan Hanaffi, Anas Islam, Aimen Salman, Mohd Muazzam Khan, Faiyaz Shakeel, Qiang Cai, Xiaojun Cai, Quazi T. H. Shubhra   +8 more
wiley   +1 more source