Results 41 to 50 of about 5,905,284 (252)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Revisiting Sample Allocation Methods: A Simulation-Based Comparison [PDF]

open access: yes, 2019
In stratified sampling the problem of optimally allocating the sample size is of primary importance, especially in business surveys when reliable estimates are required both for the overall population and for the domains of studies.
Martelli B. M.   +3 more
core   +1 more source

Draft allocation report pearl oyster (Pinctada maxima) resource / by the Integrated Fisheries Allocation Advisory Committee

open access: yes, 2016
Integrated Fisheries Management (IFM) is an initiative aimed at addressing the issue of how fish resources in Western Australia should be shared between competing users within the broad context of “Ecologically Sustainable Development”, or ESD, so that ...
Integrated Fisheries Allocation Advisory Committee
core   +2 more sources

Sequential-choice Random Allocation: An Efficient Process for Matching Students to Mentorships, Job Shadowing and Other Short-Term Experiential Opportunities

open access: yesJournal for Advancement of Marketing Education, 2021
## Purpose of the Study Resource allocation is more than the matching of two objects, but a systematic and efficient pairing process. Some experiential learning activities, like job-shadow assignments may create matching problems that can be solved with
Amit Poddar   +2 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

open access: yesMolecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir   +9 more
wiley   +1 more source

The multifaceted roles of lysosomes in cancer

open access: yesMolecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

MODELLING AID ALLOCATION: ISSUES, APPROACHES AND RESULTS [PDF]

open access: yes
There is a widespread view that political criteria have received less emphasis in aid allocation since the end of the cold war, with a greater share of aid subsequently being based on developmental criteria.
Mark McGillivray
core   +2 more sources

An Orthogonal Hierarchical Risk Parity Allocation Method for Improved Portfolio Out-of-Sample Performance

open access: yesIEEE Access
Quantitative risk allocation methods have attractive features, such as robust risk exposition and risk allocation control, which tend to affect their out-of-sample returns.
Kevin Gabriel Ramisch Pergher   +2 more
doaj   +1 more source

Politization of Local Government Budget Allocations in 2017 Election

open access: yesJurnal ASET (Akuntansi Riset), 2020
This paper discusses about the election of regional heads to the regional government budget allocation. This study discusses the regional budget in the period before local election and during the local election.
Mega Wahyu Widawati, Ari Kuncara Widagdo
doaj   +1 more source

Home - About - Disclaimer - Privacy