Results 91 to 100 of about 952,480 (282)
Identifying Effective Scenarios for Sample Average Approximation
, 2019 We introduce a method to improve the tractability of the well-known Sample Average Approximation (SAA) without compromising important theoretical properties, such as convergence in probability and the consistency of an independent and identically distributed (iid) sample.
openaire +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Sample Average Approximation for Stochastic Programming with Equality Constraints
SIAM Journal on OptimizationWe revisit the sample average approximation (SAA) approach for non-convex stochastic programming. We show that applying the SAA approach to problems with expected value equality constraints does not necessarily result in asymptotic optimality guarantees as the sample size increases. To address this issue, we relax the equality constraints.
Thomas Lew +2 more
openaire +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Energies, 2019 Nowadays, the hybrid wind–diesel system is widely used on small islands. However, the operation of these systems faces a major challenge in frequency control due to their small inertia.
Nhung Nguyen Hong, Yosuke Nakanishi
doaj +1 more source
Optimal surveillance against bioinvasions: a sample average approximation method applied to an agent-based spread model. [PDF]
Ecol Appl, 2021 Nguyen HT, Ha PV, Kompas T.
europepmc +1 more source
Dealing with Limited Overlap in Estimation of Average Treatment Effects [PDF]
Estimation of average treatment effects under unconfounded or ignorable treatment assignment is often hampered by lack of overlap in the covariate distributions.
Guido W. Imbens +3 more
core
Assortment Optimization and the Sample Average Approximation
We consider a simple approach to solving assortment optimization under the random utility maximization model. The approach uses Monte-Carlo simulation to construct a ranking-based choice model that serves as a proxy for the true choice model, followed by finding an assortment that is optimal with respect to that proxy.
Khalid, Hassaan, Sturt, Bradley
openaire +2 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Future Business JournalThis study introduces a stochastic mixed-integer nonlinear programming (MINLP) model designed to optimize budget allocation for digital marketing campaigns under uncertainty.
Zakaria Yahia, Mostafa ElBolok
doaj +1 more source