Results 111 to 120 of about 6,253,748 (354)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Material culture in Sixteenth Century Venice: a sample from probate inventories, 1510–1615 [PDF]

open access: yes
This paper presents a panel of data about material culture in early modern Venice. The data are taken from three samples of Venetian probate inventories drawn up voluntarily from Venetian widows in the years 1510–1615, at intervals of roughly fifty years.
Isabella Cecchini
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Method and device for detection of surface discontinuities or defects [PDF]

open access: yes, 1974
Surface discontinuities of defects such as cracks and orifices are detected by applying a penetrating fluid, preferably a liquid, to a test surface so as to cause the liquid to penetrate any minute cracks or opening in the surface, removing the excess ...
Leger, L. J.
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Carbonaceous Materials in Green Sample Preparation

open access: gold, 2023
Arpana Agrawal   +3 more
openalex   +1 more source

User's manual for GAMNAS: Geometric and Material Nonlinear Analysis of Structures [PDF]

open access: yes
GAMNAS (Geometric and Material Nonlinear Analysis of Structures) is a two dimensional finite-element stress analysis program. Options include linear, geometric nonlinear, material nonlinear, and combined geometric and material nonlinear analysis.
Dattaguru, B., Whitcomb, J. D.
core   +1 more source

Method and apparatus for determination of material residual stress [PDF]

open access: yes, 1993
A device for the determination of residual stress in a material sample consisting of a sensor coil, adjacent to the material sample, whose resistance varies according to the amount of stress within the material sample, a mechanical push-pull machine for ...
Chern, Engmin J., Flom, Yury
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Measurement of Elastoresistivity at Finite Frequency by Amplitude Demodulation

open access: yes, 2018
Elastoresistivity, the relation between resistivity and strain, can elucidate subtle properties of the electronic structure of a material and is an increasingly important tool for the study of strongly correlated materials.
Fisher, Ian R.   +5 more
core   +1 more source

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