Results 131 to 140 of about 22,781,464 (398)
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
Study The Effect of Blowing Material Which Extracted From Okra Waste in Some Properties of Natural Rubber [PDF]
Engineering and Technology Journal, 2010 The aim of this research to use extracted natural material from waste product of Okra as blowing material by simple method for production sponge rubber with good damping properties.
doaj +1 more source
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
Material culture in Sixteenth Century Venice: a sample from probate inventories, 1510–1615 [PDF]
This paper presents a panel of data about material culture in early modern Venice. The data are taken from three samples of Venetian probate inventories drawn up voluntarily from Venetian widows in the years 1510–1615, at intervals of roughly fifty years.
Isabella Cecchini
core
Pengukuran Speed dan Impedansi Akustik pada Tanah Liat dengan Memanfaatkan Sinyal Echo Ultrasonik
Jurnal Rekayasa Elektrika, 2019 Each material has its own characteristics, which are represented by the value of speed/ultrasonic wave propagation speed (C) and acoustic impedance/material resistance (Ztl).
Lusiana Lusiana +2 more
doaj +1 more source
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Robust charge and magnetic order under electric field and current in the multiferroic LuFe(2)O(4)
, 2010 We performed elastic neutron scattering measurements on the charge- and magnetically-ordered multiferroic material LuFe(2)O(4). An external electric field along the [001] direction with strength up to 20 kV/cm applied at low temperature (~100 K) does not
Gu, Genda +3 more
core +1 more source
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Measurement of Elastoresistivity at Finite Frequency by Amplitude Demodulation
, 2018 Elastoresistivity, the relation between resistivity and strain, can elucidate subtle properties of the electronic structure of a material and is an increasingly important tool for the study of strongly correlated materials.
Fisher, Ian R. +5 more
core +1 more source