Results 41 to 50 of about 213,512 (264)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Sample Path Properties of Generalized Random Sheets with Operator Scaling [PDF]

Journal of Theoretical Probability, 2020
AbstractWe consider operator scaling $$\alpha $$ α -stable random sheets, which were introduced in Hoffmann (Operator scaling stable random sheets with application to binary mixtures. Dissertation Universität Siegen, 2011). The idea behind such fields is to combine the properties of operator scaling $$\alpha $$
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Microbial co-occurrence network topological properties link with reactor parameters and reveal importance of low-abundance genera

npj Biofilms and Microbiomes, 2022
Operational factors and microbial interactions affect the ecology in anaerobic digestion systems. From 12 lab-scale reactors operated under distinct engineering conditions, bacterial communities were found driven by temperature, while archaeal ...
Bing Guo, Lei Zhang, Huijuan Sun, Mengjiao Gao, Najiaowa Yu, Qianyi Zhang, Anqi Mou, Yang Liu   +7 more
doaj   +1 more source

Cadmium oxide reinforced 46V2O5–46P2O5–(8−x)B2O3–xCdO semiconducting oxide glasses and resistance behaviors against ionizing gamma rays

Journal of Materials Research and Technology, 2021
This study aimed to determine the contribution of B2O3/CdO substitution on gamma-ray attenuation behaviors of 46V2O5–46P2O5–(8−x)B2O3–xCdO (x = 0–8 mol%) glass system.
H.O. Tekin, Shams A.M. Issa, G. Kilic, Hesham M.H. Zakaly, A. Badawi, G. Bilal, H.A.A. Sidek, K.A. Matori, M.H.M. Zaid   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Deposition process and mechanical properties of magnesium alloy inclined thin-walls fabricated by wire-arc additive manufacturing

Cailiao gongcheng
Wire-arc additive manufacturing is a new type of manufacture using wire as filling material and arc as a heat source， making it easier to manufacture complex-shaped and big-sized parts.
ZHENG Yuanxuan, HAN Qifei, CHEN Binling, GUO Yueling, TAN Li, LI Xingchen, PENG Siyi, LIU Changmeng   +7 more
doaj   +1 more source