Results 61 to 70 of about 1,177,360 (314)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Microbial co-occurrence network topological properties link with reactor parameters and reveal importance of low-abundance genera

npj Biofilms and Microbiomes, 2022
Operational factors and microbial interactions affect the ecology in anaerobic digestion systems. From 12 lab-scale reactors operated under distinct engineering conditions, bacterial communities were found driven by temperature, while archaeal ...
Bing Guo, Lei Zhang, Huijuan Sun, Mengjiao Gao, Najiaowa Yu, Qianyi Zhang, Anqi Mou, Yang Liu   +7 more
doaj   +1 more source

Cadmium oxide reinforced 46V2O5–46P2O5–(8−x)B2O3–xCdO semiconducting oxide glasses and resistance behaviors against ionizing gamma rays

Journal of Materials Research and Technology, 2021
This study aimed to determine the contribution of B2O3/CdO substitution on gamma-ray attenuation behaviors of 46V2O5–46P2O5–(8−x)B2O3–xCdO (x = 0–8 mol%) glass system.
H.O. Tekin, Shams A.M. Issa, G. Kilic, Hesham M.H. Zakaly, A. Badawi, G. Bilal, H.A.A. Sidek, K.A. Matori, M.H.M. Zaid   +8 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The rise of the C IV mass density at z<2.5 [PDF]

, 2010
The cosmic evolution of the metal content of the intergalactic medium puts stringent constraints on the properties of galactic outflows and on the nature of UV background.
Adelberger, Asplund, Becker, Bergeron, Bolton, Bunker, Cooksey, D'Odorico, Dekker, Ellison, Fontana, Francesco Calura, Madau, Matteo Viel, Oppenheimer, Oppenheimer, Pettini, Pettini, Porciani, Ryan-Weber, Ryan-Weber, Saitta, Scannapieco, Schaye, Simcoe, Simcoe, Songaila, Stefano Cristiani, Steidel, Storrie-Lombardi, Tytler, Valentina D'Odorico   +31 more
core   +2 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

On zeros of Martin-L\"of random Brownian motion [PDF]

, 2014
We investigate the sample path properties of Martin-L\"of random Brownian motion. We show (1) that many classical results which are known to hold almost surely hold for every Martin-L\"of random Brownian path, (2) that the effective dimension of zeroes ...
Allen, Kelty, Bienvenu, Laurent, Slaman, Theodore   +2 more
core  

Asymptotic behaviour of random tridiagonal Markov chains in biological applications

, 2012
Discrete-time discrete-state random Markov chains with a tridiagonal generator are shown to have a random attractor consisting of singleton subsets, essentially a random path, in the simplex of probability vectors.
A. E. Hutzenthaler, A. Leizarowitz, B. Noble, B. S. Thomson, D. J. Hartfiel, D. J. Hartfiel, D. N. Cheban, D. Wodarz, E. Asarin, H. Cohn, I. Chueshov, I. Chueshov, J. Wolfowitz, J.-P. Aubin, L. Arnold, L. J. S. Allen, M. A. Krasnosel$'$skij, M. F. Barnsley, M. Neumann, P. E. Kloeden, P. Imkeller, P. J. Bushell   +21 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Increments and sample path properties of Gaussian processes

Chinese Science Bulletin, 1999
The authors present an excellent review of results of law of iterated logarithm type and related results for the increments of sample paths of Gaussian processes. In particular, results pertaining to Brownian motion and fractional Brownian motion are discussed.
Lin, Zhengyan, Zhang, Lixin
openaire   +1 more source