Results 141 to 150 of about 13,319,037 (325)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Innovative sample preparation techniques in food analysis: the rise of compressed fluids and novel solvents

open access: yesAdvances in Sample Preparation
Compressed fluids and novel green solvents represent the most promising approaches for achieving sustainable sample preparation in food analysis. Traditional extraction techniques often rely on toxic organic solvents and energy-intensive processes ...
Luana C. dos Santos   +4 more
doaj   +1 more source

Automated sample preparation in a microfluidic culture device for cellular metabolomics

open access: green, 2016
Laura A. Filla   +3 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

A Fast and Economical Sample Preparation Protocol for Interaction Proteomics Analysis

open access: hybrid, 2019
Miguel A. Gonzalez‐Lozano   +4 more
openalex   +1 more source

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